@article{e91a4afe73ca40e9a77342669e5733a8,
title = "Prognostic importance of lymph node count and ratio in rectal cancer after neoadjuvant chemoradiotherapy: Results from a cross-sectional study",
abstract = "BACKGROUND: The aim of this study was to determine the prognostic value of lymph node count (LNC) and lymph node ratio (LNR) in rectal cancer after neoadjuvant chemoradiotherapy (CRT).METHODS: Patients who underwent neoadjuvant CRT and total mesorectal excision (TME) for Stage I-III rectal cancer were selected from a cross-sectional study including 71 Dutch centres. Primary outcome parameters were disease-free survival (DFS) and overall survival (OS). Prognostic significance of LNC and LNR (cut-off values 0.15, 0.20, 0.30) was tested for different (sub)groups.RESULTS:From 2095 registered patients, 458 were included, of which 240 patients with LNC < 12 and 218 patients with LNC ≥ 12. LNC was not significantly associated with DFS (p = 0.35) and OS (p = 0.59). In univariable analysis, LNR was significantly associated with DFS and OS in the whole cohort and LNC subgroups, but not in multivariable analysis.CONCLUSIONS: LNC was not associated with long-term oncological outcome in rectal cancer patients treated with CRT, nor was LNR when corrected for N-stage. However, LNR might be used to identify subgroups of node-positive patients with a favourable outcome.",
author = "{The Dutch Snapshot Research Group} and Tanis, {Pieter J.} and Aalbers, {A. G.J.} and Bakker, {I. S.} and Bartels, {S. A.} and Bastiaansen, {A. J.N.M.} and J. Blok and Bosker, {R. J.I.} and Bouvy, {N. D.} and H. Bouwman and A. Brandt-Kerkhof and Brinkman, {D. J.} and S. Bruin and Burger, {J. W.A.} and Coene, {P. P.L.O.} and {de Graaf}, {E. J.R.} and {de Groot}, I. and {de Vos tot Nederveen Cappel}, {R. J.} and {den Boer}, {F. C.} and Dekker, {J. W.T.} and A. Demirkiran and F. Ferenschild and Foppen, {J. W.} and P. Gerven and {Van Grevenstein}, {W. M.U.} and R. Haen and Harlaar, {J. J.} and {van der Harst}, E. and J. Heemskerk and Heeren, {J. F.} and B. Heijnen and C. Hoff and W. Hogendoorn and A. Huijbers and P. Janssen and Jonker, {F. H.} and A. Keijzer and Kool, {M. E.} and Kuiper, {J. T.} and Lange, {J. F.} and E. Madsen and Menon, {A. G.} and Musters, {G. D.} and J. Nonner and Oosterling, {S. J.} and Paul, {P. M.P.} and Rutten, {H. J.} and A. Rutten and N. Schouten and Schreuder, {A. M.} and Slooter, {G. D.} and Snijders, {H. S.} and Sonneveld, {D. J.A.} and {Spillenaar Bilgen}, {E. J.} and Groen, {H. A.} and {ten Hoeve}, {H. G.} and L. Tseng and {van Beek}, {S. C.} and {van de Ven}, {A. W.H.} and {van den Berg}, C. and {van der Hul}, R. and {van der Schelling}, G. and {van der Spek}, A. and {van Eekelen}, C. and {van Essen}, {J. A.} and {van Kessel}, C. and {van Loon}, {Y. T.} and {van Rijswijk}, A. and {van Rooijen}, {S. J.} and {van Steensel}, L. and S. Vijfhuize and Vles, {W. J.} and Vrijland, {W. W.} and Witjes, {C. D.M.} and Wouters, {M. W.} and Zeestraten, {E. C.} and Zimmerman, {D. D.E.}",
note = "Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC",
year = "2021",
month = sep,
day = "1",
doi = "10.1002/jso.26522",
language = "English",
volume = "124",
pages = "367--377",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "3",
}
