Prognostic relevance of limit of quantification as low-level cutoff for flow cytometry-based measurable residual disease assessment in acute myeloid leukemia

Lukas H. Haaksma; Raffaele Palmieri; Tom Reuvekamp; Jesse M. Tettero; Lok Lam Ngai; Costa Bachas; Angèle Kelder; Willemijn J. Scholten; Patrycja Gradowska; Valentina Arena; Anderson João Simione; Luca Maurillo; Adriano Venditti; Bob Löwenberg; Gert J. Ossenkoppele; David C. de Leeuw; Maura R.V. Ikoma-Colturato; Francesco Buccisano; Jacqueline Cloos

doi:10.1038/s41375-025-02825-x

Prognostic relevance of limit of quantification as low-level cutoff for flow cytometry-based measurable residual disease assessment in acute myeloid leukemia

Lukas H. Haaksma
, Raffaele Palmieri
, Tom Reuvekamp
, Jesse M. Tettero
, Lok Lam Ngai
, Costa Bachas
, Angèle Kelder
, Willemijn J. Scholten
, Patrycja Gradowska
, Valentina Arena
, Anderson João Simione
, Luca Maurillo
, Adriano Venditti
, Bob Löwenberg
, Gert J. Ossenkoppele
, David C. de Leeuw
, Maura R.V. Ikoma-Colturato
, Francesco Buccisano
, Jacqueline Cloos^*

^*Corresponding author for this work

Hematology

Vrije Universiteit Amsterdam
Amsterdam UMC
University of Rome Tor Vergata
University of Amsterdam
HOVON Foundation
GIMEMA Data Center
Hospital Amaral Carvalho - Jau - São Paulo

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

3 Citations (Scopus)

7 Downloads (Pure)

Original language	English
Pages (from-to)	435-439
Number of pages	5
Journal	Leukemia
Volume	40
Issue number	2
DOIs	https://doi.org/10.1038/s41375-025-02825-x
Publication status	Published - Feb 2026

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10.1038/s41375-025-02825-xLicence: CC BY-NC-ND

Prognostic relevance of limit of quantification as low-levelFinal published version, 612 KBLicence: CC BY-NC-ND

Cite this

Haaksma, L. H., Palmieri, R., Reuvekamp, T., Tettero, J. M., Ngai, L. L., Bachas, C., Kelder, A., Scholten, W. J., Gradowska, P., Arena, V., João Simione, A., Maurillo, L., Venditti, A., Löwenberg, B., Ossenkoppele, G. J., de Leeuw, D. C., Ikoma-Colturato, M. R. V., Buccisano, F., & Cloos, J. (2026). Prognostic relevance of limit of quantification as low-level cutoff for flow cytometry-based measurable residual disease assessment in acute myeloid leukemia. Leukemia, 40(2), 435-439. https://doi.org/10.1038/s41375-025-02825-x

@article{4cd2ec23ed774926b776be9098caec68,

title = "Prognostic relevance of limit of quantification as low-level cutoff for flow cytometry-based measurable residual disease assessment in acute myeloid leukemia",

author = "Haaksma, \{Lukas H.\} and Raffaele Palmieri and Tom Reuvekamp and Tettero, \{Jesse M.\} and Ngai, \{Lok Lam\} and Costa Bachas and Ang{\`e}le Kelder and Scholten, \{Willemijn J.\} and Patrycja Gradowska and Valentina Arena and \{Jo{\~a}o Simione\}, Anderson and Luca Maurillo and Adriano Venditti and Bob L{\"o}wenberg and Ossenkoppele, \{Gert J.\} and \{de Leeuw\}, \{David C.\} and Ikoma-Colturato, \{Maura R.V.\} and Francesco Buccisano and Jacqueline Cloos",

year = "2026",

month = feb,

doi = "10.1038/s41375-025-02825-x",

language = "English",

volume = "40",

pages = "435--439",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Springer Nature",

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Haaksma, LH, Palmieri, R, Reuvekamp, T, Tettero, JM, Ngai, LL, Bachas, C, Kelder, A, Scholten, WJ, Gradowska, P, Arena, V, João Simione, A, Maurillo, L, Venditti, A, Löwenberg, B, Ossenkoppele, GJ, de Leeuw, DC, Ikoma-Colturato, MRV, Buccisano, F & Cloos, J 2026, 'Prognostic relevance of limit of quantification as low-level cutoff for flow cytometry-based measurable residual disease assessment in acute myeloid leukemia', Leukemia, vol. 40, no. 2, pp. 435-439. https://doi.org/10.1038/s41375-025-02825-x

Prognostic relevance of limit of quantification as low-level cutoff for flow cytometry-based measurable residual disease assessment in acute myeloid leukemia. / Haaksma, Lukas H.; Palmieri, Raffaele; Reuvekamp, Tom et al.
In: Leukemia, Vol. 40, No. 2, 02.2026, p. 435-439.

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

TY - JOUR

T1 - Prognostic relevance of limit of quantification as low-level cutoff for flow cytometry-based measurable residual disease assessment in acute myeloid leukemia

AU - Haaksma, Lukas H.

AU - Palmieri, Raffaele

AU - Reuvekamp, Tom

AU - Tettero, Jesse M.

AU - Ngai, Lok Lam

AU - Bachas, Costa

AU - Kelder, Angèle

AU - Scholten, Willemijn J.

AU - Gradowska, Patrycja

AU - Arena, Valentina

AU - João Simione, Anderson

AU - Maurillo, Luca

AU - Venditti, Adriano

AU - Löwenberg, Bob

AU - Ossenkoppele, Gert J.

AU - de Leeuw, David C.

AU - Ikoma-Colturato, Maura R.V.

AU - Buccisano, Francesco

AU - Cloos, Jacqueline

PY - 2026/2

Y1 - 2026/2

UR - https://www.scopus.com/pages/publications/105024719781

U2 - 10.1038/s41375-025-02825-x

DO - 10.1038/s41375-025-02825-x

M3 - Comment/Letter to the editor

C2 - 41372597

AN - SCOPUS:105024719781

SN - 0887-6924

VL - 40

SP - 435

EP - 439

JO - Leukemia

JF - Leukemia

IS - 2

ER -

Prognostic relevance of limit of quantification as low-level cutoff for flow cytometry-based measurable residual disease assessment in acute myeloid leukemia

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