Prognostic Value of Microvascular Obstruction and Infarct Size, as Measured by CMR in STEMI Patients

Matthijs Kranenburg, Michael Magro, H Thiele, S de Waha, I Eitel, A Cochet, Y Coffin, D Atar, P Buser, E Wu, D van der Lee, V Bodi, G Klug, B Metzler, R Delewi, P Bernhardt, W Rottbauer, Eric Boersma, Felix Zijlstra, Robert Jan van Geuns

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The aim of this study was to evaluate the value of microvascular obstruction (MO) and infarct size as a percentage of left ventricular mass (15%LV), as measured by contrast-enhanced cardiac magnetic resonance, in predicting major cardiovascular adverse events (MACE) at 2 years in patients with ST-segment elevation myocardial infarction reperfused by primary percutaneous coronary intervention. Individual data from 1,025 patients were entered into the pooled analysis. MO was associated with the occurrence of MACE, defined as a composite of cardiac death, congestive heart failure, and myocardial re-infarction (adjusted hazard ratio: 3.74; 95% confidence interval: 2.21 to 6.34). IS% LV >= 25% was not associated with MACE (adjusted hazard ratio: 0.90; 95% confidence interval: 0.59 to 1.37). The authors conclude that MO is an independent predictor of MACE and cardiac death, whereas IS%LV is not independently associated with MACE. (C) 2014 by the American College of Cardiology Foundation.
Original languageUndefined/Unknown
Pages (from-to)930-939
Number of pages10
JournalJACC-cardiovascular imaging
Issue number9
Publication statusPublished - 2014

Research programs

  • EMC COEUR-09
  • EMC NIHES-03-30-01

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