Prognostic Value of Microvascular Obstruction and Infarct Size, as Measured by CMR in STEMI Patients

Matthijs Kranenburg; Michael Magro; H Thiele; S de Waha; I Eitel; A Cochet; Y Coffin; D Atar; P Buser; E Wu; D van der Lee; V Bodi; G Klug; B Metzler; R Delewi; P Bernhardt; W Rottbauer; Eric Boersma; Felix Zijlstra; Robert Jan van Geuns

doi:10.1016/j.jcmg.2014.05.010

Prognostic Value of Microvascular Obstruction and Infarct Size, as Measured by CMR in STEMI Patients

Matthijs Kranenburg, Michael Magro, H Thiele, S de Waha, I Eitel, A Cochet, Y Coffin, D Atar, P Buser, E Wu, D van der Lee, V Bodi, G Klug, B Metzler, R Delewi, P Bernhardt, W Rottbauer, Eric Boersma, Felix Zijlstra, Robert Jan van Geuns

Cardiology

Research output: Contribution to journal › Article › Academic

289 Citations (Scopus)

Abstract

The aim of this study was to evaluate the value of microvascular obstruction (MO) and infarct size as a percentage of left ventricular mass (15%LV), as measured by contrast-enhanced cardiac magnetic resonance, in predicting major cardiovascular adverse events (MACE) at 2 years in patients with ST-segment elevation myocardial infarction reperfused by primary percutaneous coronary intervention. Individual data from 1,025 patients were entered into the pooled analysis. MO was associated with the occurrence of MACE, defined as a composite of cardiac death, congestive heart failure, and myocardial re-infarction (adjusted hazard ratio: 3.74; 95% confidence interval: 2.21 to 6.34). IS% LV >= 25% was not associated with MACE (adjusted hazard ratio: 0.90; 95% confidence interval: 0.59 to 1.37). The authors conclude that MO is an independent predictor of MACE and cardiac death, whereas IS%LV is not independently associated with MACE. (C) 2014 by the American College of Cardiology Foundation.

Original language	Undefined/Unknown
Pages (from-to)	930-939
Number of pages	10
Journal	JACC-cardiovascular imaging
Volume	7
Issue number	9
DOIs	https://doi.org/10.1016/j.jcmg.2014.05.010
Publication status	Published - 2014

Research programs

EMC COEUR-09
EMC NIHES-03-30-01

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10.1016/j.jcmg.2014.05.010

Cite this

Kranenburg, M., Magro, M., Thiele, H., de Waha, S., Eitel, I., Cochet, A., Coffin, Y., Atar, D., Buser, P., Wu, E., van der Lee, D., Bodi, V., Klug, G., Metzler, B., Delewi, R., Bernhardt, P., Rottbauer, W., Boersma, E., Zijlstra, F., & van Geuns, R. J. (2014). Prognostic Value of Microvascular Obstruction and Infarct Size, as Measured by CMR in STEMI Patients. JACC-cardiovascular imaging, 7(9), 930-939. https://doi.org/10.1016/j.jcmg.2014.05.010

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title = "Prognostic Value of Microvascular Obstruction and Infarct Size, as Measured by CMR in STEMI Patients",

abstract = "The aim of this study was to evaluate the value of microvascular obstruction (MO) and infarct size as a percentage of left ventricular mass (15%LV), as measured by contrast-enhanced cardiac magnetic resonance, in predicting major cardiovascular adverse events (MACE) at 2 years in patients with ST-segment elevation myocardial infarction reperfused by primary percutaneous coronary intervention. Individual data from 1,025 patients were entered into the pooled analysis. MO was associated with the occurrence of MACE, defined as a composite of cardiac death, congestive heart failure, and myocardial re-infarction (adjusted hazard ratio: 3.74; 95% confidence interval: 2.21 to 6.34). IS% LV >= 25% was not associated with MACE (adjusted hazard ratio: 0.90; 95% confidence interval: 0.59 to 1.37). The authors conclude that MO is an independent predictor of MACE and cardiac death, whereas IS%LV is not independently associated with MACE. (C) 2014 by the American College of Cardiology Foundation.",

author = "Matthijs Kranenburg and Michael Magro and H Thiele and {de Waha}, S and I Eitel and A Cochet and Y Coffin and D Atar and P Buser and E Wu and {van der Lee}, D and V Bodi and G Klug and B Metzler and R Delewi and P Bernhardt and W Rottbauer and Eric Boersma and Felix Zijlstra and {van Geuns}, {Robert Jan}",

year = "2014",

doi = "10.1016/j.jcmg.2014.05.010",

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pages = "930--939",

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Kranenburg, M, Magro, M, Thiele, H, de Waha, S, Eitel, I, Cochet, A, Coffin, Y, Atar, D, Buser, P, Wu, E, van der Lee, D, Bodi, V, Klug, G, Metzler, B, Delewi, R, Bernhardt, P, Rottbauer, W, Boersma, E , Zijlstra, F & van Geuns, RJ 2014, 'Prognostic Value of Microvascular Obstruction and Infarct Size, as Measured by CMR in STEMI Patients', JACC-cardiovascular imaging, vol. 7, no. 9, pp. 930-939. https://doi.org/10.1016/j.jcmg.2014.05.010

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T1 - Prognostic Value of Microvascular Obstruction and Infarct Size, as Measured by CMR in STEMI Patients

AU - Kranenburg, Matthijs

AU - Magro, Michael

AU - Thiele, H

AU - de Waha, S

AU - Eitel, I

AU - Cochet, A

AU - Coffin, Y

AU - Atar, D

AU - Buser, P

AU - Wu, E

AU - van der Lee, D

AU - Bodi, V

AU - Klug, G

AU - Metzler, B

AU - Delewi, R

AU - Bernhardt, P

AU - Rottbauer, W

AU - Boersma, Eric

AU - Zijlstra, Felix

AU - van Geuns, Robert Jan

PY - 2014

Y1 - 2014

N2 - The aim of this study was to evaluate the value of microvascular obstruction (MO) and infarct size as a percentage of left ventricular mass (15%LV), as measured by contrast-enhanced cardiac magnetic resonance, in predicting major cardiovascular adverse events (MACE) at 2 years in patients with ST-segment elevation myocardial infarction reperfused by primary percutaneous coronary intervention. Individual data from 1,025 patients were entered into the pooled analysis. MO was associated with the occurrence of MACE, defined as a composite of cardiac death, congestive heart failure, and myocardial re-infarction (adjusted hazard ratio: 3.74; 95% confidence interval: 2.21 to 6.34). IS% LV >= 25% was not associated with MACE (adjusted hazard ratio: 0.90; 95% confidence interval: 0.59 to 1.37). The authors conclude that MO is an independent predictor of MACE and cardiac death, whereas IS%LV is not independently associated with MACE. (C) 2014 by the American College of Cardiology Foundation.

AB - The aim of this study was to evaluate the value of microvascular obstruction (MO) and infarct size as a percentage of left ventricular mass (15%LV), as measured by contrast-enhanced cardiac magnetic resonance, in predicting major cardiovascular adverse events (MACE) at 2 years in patients with ST-segment elevation myocardial infarction reperfused by primary percutaneous coronary intervention. Individual data from 1,025 patients were entered into the pooled analysis. MO was associated with the occurrence of MACE, defined as a composite of cardiac death, congestive heart failure, and myocardial re-infarction (adjusted hazard ratio: 3.74; 95% confidence interval: 2.21 to 6.34). IS% LV >= 25% was not associated with MACE (adjusted hazard ratio: 0.90; 95% confidence interval: 0.59 to 1.37). The authors conclude that MO is an independent predictor of MACE and cardiac death, whereas IS%LV is not independently associated with MACE. (C) 2014 by the American College of Cardiology Foundation.

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DO - 10.1016/j.jcmg.2014.05.010

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