Prognostic value of post-percutaneous coronary intervention diastolic pressure ratio

K. Masdjedi, L. J.C. van Zandvoort, T. Neleman, I. Kardys, J. Ligthart, W. K. Den Dekker, R. Diletti, F. Zijlstra, N. M. Van Mieghem, J. Daemen*

*Corresponding author for this work

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Abstract

Aim: To evaluate the distribution of a generic diastolic pressure ratio (dPR) after angiographically successful percutaneous coronary intervention (PCI) and to assess its association with the 2‑year incidence of target vessel failure (TVF), defined as a composite of cardiac mortality, target vessel revascularisation, target vessel myocardial infarction and stent thrombosis. Methods: The dPR SEARCH study is a post hoc analysis of the prospective single-centre FFR-SEARCH registry, in which physiological assessment was performed after angiographically successful PCI in a total of 1000 patients, using a dedicated microcatheter. dPR was calculated offline with recently validated software in a subset of 735 patients. Results: Mean post-PCI dPR was 0.95 ± 0.06. Post-PCI dPR was ≤ 0.89 in 15.2% of the patients. The cumulative incidence of TVF at 2‑year follow-up was 9.4% in patients with a final post-PCI dPR ≤ 0.89 as compared to 6.1% in patients with a post-PCI dPR > 0.89 (adjusted hazard ratio [HR] for dPR ≤ 0.89: 1.53; 95% CI 0.74–3.13; p = 0.249). dPR ≤ 0.89 was associated with significantly higher cardiac mortality at 2 years; adjusted HR 2.40; 95% CI 1.01–5.68; p = 0.047. Conclusions: In a real-world setting, despite optimal angiographic PCI results, 15.2% of the patients had a final post-PCI dPR of ≤ 0.89, which was associated with a higher incidence of TVF and a significantly higher cardiac mortality rate.

Original languageEnglish
Pages (from-to)352-359
Number of pages8
JournalNetherlands Heart Journal
Volume30
Issue number7-8
DOIs
Publication statusPublished - Jul 2022

Bibliographical note

Funding Information:
K. Masdjedi: institutional research grant support from ACIST Medical. L.J.C. van Zandvoort: institutional research grant support from ACIST Medical. N.M. Van Mieghem: research grant support from Edwards, Medtronic, Abbott, Boston Scientific, Pulse Cath, ACIST Medical, Essential Medical. J. Daemen: institutional grant/research support from Astra Zeneca, Abbott Vascular, Boston Scientific, ACIST Medical, Medtronic, Pie Medical, and ReCor Medical. T. Neleman, I. Kardys, J. Ligthart, W.K. Den Dekker, R. Diletti and F. Zijlstra declare that they have no competing interests.

Publisher Copyright:
© 2022, The Author(s).

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