TY - JOUR
T1 - Prognostic value of SYNTAX score, intravascular ultrasound and near-infrared spectroscopy in coronary disease
T2 - 12-year follow-up of ATHEROREMO
AU - Meuleman, Victor G.
AU - Vanmaele, Alexander
AU - Da Veiga Fernandes de Mira, Jose M.
AU - Akkerhuis, K. Martijn
AU - Oemrawsingh, Rohit M.
AU - Vroegindewey, Maxime M.
AU - Cheng, Jin M.
AU - Garcia-Garcia, Hector M.
AU - Daemen, Joost
AU - van Mieghem, Nicolas M.
AU - Serruys, Patrick W.
AU - van Geuns, Robert Jan
AU - Boersma, Eric
AU - Kardys, Isabella
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2026/1
Y1 - 2026/1
N2 - Background and aims: This study aims to investigate the very long-term predictive value of the SYNTAX score and plaque characteristics derived by intravascular ultrasound (IVUS) as well as near-infrared spectroscopy (NIRS), for all-cause mortality in patients with low to intermediate complex coronary artery disease. Methods: We evaluated 581 patients with chronic or acute coronary syndrome from the European Collaborative Project on Inflammation and Vascular Wall Remodeling in Atherosclerosis (ATHEROREMO) cohort. Flow-limiting lesions were treated with intracoronary stenting. IVUS-VH (n = 581) and NIRS (n = 195) images were obtained in a non-culprit segment ≥ 40 mm. Cox models were applied to relate pre-PCI SYNTAX score and plaque characteristics to very long-term all-cause mortality. Adjusted hazard ratios (aHR), corrected for cardiovascular comorbidities and risk factors, are reported per doubling of the corresponding variable. Results: Mean (standard deviation) age was 62 (11) years; 76% were men; median SYNTAX score was 9.0 (25th–75th percentile 4.0–15.0). Median follow-up was 12.8 (25th–75th percentile 10.1–13.4) years, and 177 cases of all-cause mortality occurred. SYNTAX score (aHR 1.25, 95% confidence interval [CI] 1.05–1.48; p = 0.012) and percentage dense calcified plaque (aHR 1.21 [1.02–1.42]; p = 0.026) were associated with increased mortality risk, while fibrous plaque (aHR 0.54 [0.34–0.87]; p = 0.011) was related to reduced risk. NIRS features were not associated with very long-term mortality. Conclusion: Angiography-based SYNTAX score and IVUS-VH-defined fibrous and dense calcified plaque were related to 12-year mortality in patients with low-to-intermediate complex CAD.
AB - Background and aims: This study aims to investigate the very long-term predictive value of the SYNTAX score and plaque characteristics derived by intravascular ultrasound (IVUS) as well as near-infrared spectroscopy (NIRS), for all-cause mortality in patients with low to intermediate complex coronary artery disease. Methods: We evaluated 581 patients with chronic or acute coronary syndrome from the European Collaborative Project on Inflammation and Vascular Wall Remodeling in Atherosclerosis (ATHEROREMO) cohort. Flow-limiting lesions were treated with intracoronary stenting. IVUS-VH (n = 581) and NIRS (n = 195) images were obtained in a non-culprit segment ≥ 40 mm. Cox models were applied to relate pre-PCI SYNTAX score and plaque characteristics to very long-term all-cause mortality. Adjusted hazard ratios (aHR), corrected for cardiovascular comorbidities and risk factors, are reported per doubling of the corresponding variable. Results: Mean (standard deviation) age was 62 (11) years; 76% were men; median SYNTAX score was 9.0 (25th–75th percentile 4.0–15.0). Median follow-up was 12.8 (25th–75th percentile 10.1–13.4) years, and 177 cases of all-cause mortality occurred. SYNTAX score (aHR 1.25, 95% confidence interval [CI] 1.05–1.48; p = 0.012) and percentage dense calcified plaque (aHR 1.21 [1.02–1.42]; p = 0.026) were associated with increased mortality risk, while fibrous plaque (aHR 0.54 [0.34–0.87]; p = 0.011) was related to reduced risk. NIRS features were not associated with very long-term mortality. Conclusion: Angiography-based SYNTAX score and IVUS-VH-defined fibrous and dense calcified plaque were related to 12-year mortality in patients with low-to-intermediate complex CAD.
UR - https://www.scopus.com/pages/publications/105018765410
U2 - 10.1007/s00392-025-02756-8
DO - 10.1007/s00392-025-02756-8
M3 - Article
C2 - 41081836
AN - SCOPUS:105018765410
SN - 1861-0684
VL - 115
SP - 78
EP - 88
JO - Clinical Research in Cardiology
JF - Clinical Research in Cardiology
IS - 1
ER -