Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics

Jayaseelan Murugaiyan*, P. Anand Kumar, G. Srinivasa Rao, Katia Iskandar, Stephen Hawser, John P. Hays, Yara Mohsen, Saranya Adukkadukkam, Wireko Andrew Awuah, Ruiz Alvarez Maria Jose, Nanono Sylvia, Esther Patience Nansubuga, Bruno Tilocca, Paola Roncada, Natalia Roson-Calero, Javier Moreno-Morales, Rohul Amin, Ballamoole Krishna Kumar, Abishek Kumar, Abdul Rahman ToufikThaint Nadi Zaw, Oluwatosin O. Akinwotu, Maneesh Paul Satyaseela, Maarten B.M. van Dongen

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

17 Citations (Scopus)
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Abstract

Antibiotic resistance, and, in a broader perspective, antimicrobial resistance (AMR), continues to evolve and spread beyond all boundaries. As a result, infectious diseases have become more challenging or even impossible to treat, leading to an increase in morbidity and mortality. Despite the failure of conventional, traditional antimicrobial therapy, in the past two decades, no novel class of antibiotics has been introduced. Consequently, several novel alternative strategies to combat these (multi-) drug-resistant infectious microorganisms have been identified. The purpose of this review is to gather and consider the strategies that are being applied or proposed as potential alternatives to traditional antibiotics. These strategies include combination therapy, techniques that target the enzymes or proteins responsible for antimicrobial resistance, resistant bacteria, drug delivery systems, physicochemical methods, and unconventional techniques, including the CRISPRCas system. These alternative strategies may have the potential to change the treatment of multidrug-resistant pathogens in human clinical settings.

Original languageEnglish
Article number200
JournalAntibiotics
Volume11
Issue number2
DOIs
Publication statusPublished - 4 Feb 2022

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© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

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