TY - JOUR
T1 - Proportions of circulating transitional B cells associate with MRI activity in interferon beta-treated multiple sclerosis patients
AU - Mimpen, Max
AU - Damoiseaux, Jan
AU - van Doorn, William
AU - Rolf, Linda
AU - Muris, Anne Hilde
AU - Hupperts, Raymond
AU - van Luijn, Marvin M.
AU - Gerlach, Oliver
AU - Smolders, Joost
N1 - Funding Information:
This study was funded by Nationaal MS Fonds grant OZ2016-001 and an unrestricted grant by Merck.
Publisher Copyright:
© 2021 The Authors
PY - 2021/9/15
Y1 - 2021/9/15
N2 - B-cells contribute to MS pathogenesis. The association of circulating B-cell phenotypes with combined unique active lesions (CUA) on MRI at 48 weeks follow-up was investigated in 50 interferon beta-treated MS patients. Transitional B-cell proportions were lower in participants with CUA at week 0 and 48 [p = 0.004, p = 0.002]. A decrease in circulating anti-EBNA-1 IgG levels between week 0 and 48 associated with absence of CUA [p = 0.047], but not with B-cell profiles. In a multi-factor model for CUA-risk, transitional B-cell proportions contributed independent from NK/T-cell ratio, change in anti-EBNA-1 IgG, and vitamin D supplementation. Transitional B-cells may predict treatment response in MS.
AB - B-cells contribute to MS pathogenesis. The association of circulating B-cell phenotypes with combined unique active lesions (CUA) on MRI at 48 weeks follow-up was investigated in 50 interferon beta-treated MS patients. Transitional B-cell proportions were lower in participants with CUA at week 0 and 48 [p = 0.004, p = 0.002]. A decrease in circulating anti-EBNA-1 IgG levels between week 0 and 48 associated with absence of CUA [p = 0.047], but not with B-cell profiles. In a multi-factor model for CUA-risk, transitional B-cell proportions contributed independent from NK/T-cell ratio, change in anti-EBNA-1 IgG, and vitamin D supplementation. Transitional B-cells may predict treatment response in MS.
UR - http://www.scopus.com/inward/record.url?scp=85110576472&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2021.577664
DO - 10.1016/j.jneuroim.2021.577664
M3 - Article
C2 - 34280843
AN - SCOPUS:85110576472
SN - 0165-5728
VL - 358
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
M1 - 577664
ER -