Prorenin anno 2008

Jan Danser, Wendy Batenburg, Joep Esch, Manne Krop

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Abstract

For many years, prorenin has been considered to be nothing more than the inactive precursor of renin. Yet, its elevated levels in diabetic subjects with microvascular complications and its extrarenal production at various sites in the body suggest otherwise. This review discusses the origin, regulation, and enzymatic activity of prorenin, its role during renin inhibition, and the angiotensin-dependent and angiotensin-independent consequences of its binding to the recently discovered (pro)renin receptor. The review ends with the concept that prorenin rather than renin determines tissue angiotensin generation.
Original languageUndefined/Unknown
Pages (from-to)655-658
Number of pages4
JournalJournal of Molecular Medicine
Volume86
Issue number6
DOIs
Publication statusPublished - 2008

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