Prorenin periconceptionally and in pregnancy: Does it have a physiological role?

Rosalieke Wiegel, Frauke von Versen-Höynck, Régine Steegers - Theunissen, Eric Steegers, AHJ Danser

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)
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Pregnancy demands major cardiovascular, renal and endocrine changes to provide an adequate blood supply for the growing fetus. The renin-angiotensin-aldosterone system plays a key role in this adaptation process. One of its components, prorenin, is released in significant amounts from the ovary and uteroplacental unit. This review describes the sources of prorenin in the periconception period and in pregnancy, including its modulation by in-vitro fertilization protocols, and discusses its potential effects, among others focusing on preeclampsia. It ends with discussing the long-term consequences, even in later life, of inappropriate renin-angiotensin-aldosterone system activity in pregnancy and offers directions for future research. Ultimately, a full understanding of the role of prorenin periconceptionally and during pregnancy will help to develop tools to diagnose and/or prevent reproductive complications.

Original languageEnglish
Article number111118
JournalMolecular and Cellular Endocrinology
Early online date17 Dec 2020
Publication statusPublished - 15 Feb 2021

Bibliographical note

Funding Information:
Department of Obstetrics and Gynecology of the Erasmus Medical Center, Rotterdam, The Netherlands. This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors.

Publisher Copyright:
© 2020 The Author(s)

Research programs

  • EMC OR-01


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