Prospective Studies on the Risk of Rheumatoid Arthritis: The European Risk RA Registry

Paul Studenic*, Aase Hensvold, Arnd Kleyer, Annette van der Helm-van Mil, Arthur G. Pratt, Daniela Sieghart, Gerhard Krönke, Ruth Williams, Savia de Souza, Susanne Karlfeldt, Martina Johannesson, Niels Steen Krogh, Lars Klareskog, Anca I. Catrina

*Corresponding author for this work

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Abstract

Background: The accumulation of risk for the development of rheumatoid arthritis (RA) is regarded as a continuum that may start with interacting environmental and genetic factors, proceed with the initiation of autoimmunity, and result in the formation of autoantibodies such as anti-citrullinated peptide antibodies (ACPA). In parallel, at-risk individuals may be asymptomatic or experience joint pain (arthralgia) that is itself non-specific or clinically suspicious for evolving RA, even in the absence of overt arthritis. Optimal strategies for the management of people at-risk of RA, both for symptom control and to delay or prevent progression to classifiable disease, remain poorly understood. Methods: To help address this, groups of stakeholders from academia, clinical rheumatology, industry and patient research partners have collaborated to advance understanding, define and study different phases of the at-risk state. In this current report we describe different European initiatives in the field and the successful effort to build a European Registry of at-risk people to facilitate observational and interventional research. Results: We outline similarities and differences between cohorts of at-risk individuals at institutions spanning several countries, and how to best combine them within the new database. Over the past 2 years, besides building the technical infrastructure, we have agreed on a core set of variables that all partners should strive to collect for harmonization purposes. Conclusion: We emphasize to address this process from different angles and touch on the biologic, epidemiologic, analytic, and regulatory aspects of collaborative studies within a meta-database of people at-risk of RA.

Original languageEnglish
Article number824501
JournalFrontiers in Medicine
Volume9
DOIs
Publication statusPublished - 22 Feb 2022

Bibliographical note

Funding Information:
The RTCure project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under Grant Agreement no. 777357. This joint undertaking receives support from the European Union's Horizon 2020 Research and Innovation Programme and EFPIA. PS has been supported by the FOREUM research fellowship grant. The Newcastle (NEAC) cohort receives infrastructural support via the National Institute for Health Research Newcastle Biomedical Research Centre.

Publisher Copyright:
Copyright © 2022 Studenic, Hensvold, Kleyer, van der Helm-van Mil, Pratt, Sieghart, Krönke, Williams, de Souza, Karlfeldt, Johannesson, Krogh, Klareskog and Catrina.

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