Protective efficacy of an RBD-based Middle East respiratory syndrome coronavirus (MERS-CoV) particle vaccine in llamas

Jordi Rodon; Anna Z Mykytyn; Guillermo Cantero; Irina C Albulescu; Berend-Jan Bosch; Alexander Brix; Jean-Christophe Audonnet; Albert Bensaid; Júlia Vergara-Alert; Bart L Haagmans; Joaquim Segalés

doi:10.1186/s42522-022-00068-9

Protective efficacy of an RBD-based Middle East respiratory syndrome coronavirus (MERS-CoV) particle vaccine in llamas

Jordi Rodon, Anna Z Mykytyn, Guillermo Cantero, Irina C Albulescu, Berend-Jan Bosch, Alexander Brix, Jean-Christophe Audonnet, Albert Bensaid, Júlia Vergara-Alert, Bart L Haagmans^*, Joaquim Segalés

^*Corresponding author for this work

Virology

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Ongoing outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) continue posing a global health threat. Vaccination of livestock reservoir species is a recommended strategy to prevent spread of MERS-CoV among animals and potential spillover to humans. Using a direct-contact llama challenge model that mimics naturally occurring viral transmission, we tested the efficacy of a multimeric receptor binding domain (RBD) particle-display based vaccine candidate. While MERS-CoV was transmitted to naive animals exposed to virus-inoculated llamas, immunization induced robust virus-neutralizing antibody responses and prevented transmission in 1/3 vaccinated, in-contact animals. Our exploratory study supports further improvement of the RBD-based vaccine to prevent zoonotic spillover of MERS-CoV.

Original language	English
Article number	12
Journal	One Health Outlook
Volume	4
Issue number	1
DOIs	https://doi.org/10.1186/s42522-022-00068-9
Publication status	Published - 24 Jun 2022

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Rodon, J., Mykytyn, A. Z., Cantero, G., Albulescu, I. C., Bosch, B.-J., Brix, A., Audonnet, J.-C., Bensaid, A., Vergara-Alert, J., Haagmans, B. L., & Segalés, J. (2022). Protective efficacy of an RBD-based Middle East respiratory syndrome coronavirus (MERS-CoV) particle vaccine in llamas. One Health Outlook, 4(1), Article 12. https://doi.org/10.1186/s42522-022-00068-9

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abstract = "Ongoing outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) continue posing a global health threat. Vaccination of livestock reservoir species is a recommended strategy to prevent spread of MERS-CoV among animals and potential spillover to humans. Using a direct-contact llama challenge model that mimics naturally occurring viral transmission, we tested the efficacy of a multimeric receptor binding domain (RBD) particle-display based vaccine candidate. While MERS-CoV was transmitted to naive animals exposed to virus-inoculated llamas, immunization induced robust virus-neutralizing antibody responses and prevented transmission in 1/3 vaccinated, in-contact animals. Our exploratory study supports further improvement of the RBD-based vaccine to prevent zoonotic spillover of MERS-CoV.",

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AU - Rodon, Jordi

AU - Mykytyn, Anna Z

AU - Cantero, Guillermo

AU - Albulescu, Irina C

AU - Bosch, Berend-Jan

AU - Brix, Alexander

AU - Audonnet, Jean-Christophe

AU - Bensaid, Albert

AU - Vergara-Alert, Júlia

AU - Haagmans, Bart L

AU - Segalés, Joaquim

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AB - Ongoing outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) continue posing a global health threat. Vaccination of livestock reservoir species is a recommended strategy to prevent spread of MERS-CoV among animals and potential spillover to humans. Using a direct-contact llama challenge model that mimics naturally occurring viral transmission, we tested the efficacy of a multimeric receptor binding domain (RBD) particle-display based vaccine candidate. While MERS-CoV was transmitted to naive animals exposed to virus-inoculated llamas, immunization induced robust virus-neutralizing antibody responses and prevented transmission in 1/3 vaccinated, in-contact animals. Our exploratory study supports further improvement of the RBD-based vaccine to prevent zoonotic spillover of MERS-CoV.

U2 - 10.1186/s42522-022-00068-9

DO - 10.1186/s42522-022-00068-9

M3 - Article

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JO - One Health Outlook

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ER -

Protective efficacy of an RBD-based Middle East respiratory syndrome coronavirus (MERS-CoV) particle vaccine in llamas

Abstract

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