Protocol for analyzing emergence dynamics of diabetes with obesity using numerical continuation and bifurcation analysis

Vehpi Yildirim*, Peter M.A. Sloot*

*Corresponding author for this work

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Abstract

Type 2 diabetes (T2D) is a multifactorial disease that slowly and inconspicuously progresses over years. Here, we present a protocol for analyzing slow progression dynamics of T2D with obesity. We describe steps for using software to exploit the differences between the timescales of the metabolic variables and using numerical continuation and bifurcation analysis. We detail procedures to analyze bi-stable system dynamics and identify the thresholds that separate healthy and diabetic states. For complete details on the use and execution of this protocol, please refer to Yildirim et al. (2023).1

Original languageEnglish
Article number102880
JournalSTAR Protocols
Volume5
Issue number1
DOIs
Publication statusPublished - 15 Mar 2024

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