Psychosis and brain volume changes during the first five years of schizophrenia

W. Cahn, M. Rais, F. P. Stigter, N. E.M. van Haren, E. Caspers, H. E. Hulshoff Pol, Z. Xu, H. G. Schnack, R. S. Kahn*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

95 Citations (Scopus)


The underlying mechanisms explaining brain volume changes in schizophrenia are not yet understood, but psychosis might be related to these changes. Forty-eight patients with first-episode schizophrenia underwent Magnetic Resonance Imaging brain scanning at inclusion and after five years. An association was found between longer duration of psychosis, larger gray matter volume decrease and larger ventricular volume increase. These findings strongly suggest that psychosis contributes to brain volume reductions found in schizophrenia.

Original languageEnglish
Pages (from-to)147-151
Number of pages5
JournalEuropean Neuropsychopharmacology
Issue number2
Publication statusPublished - Feb 2009
Externally publishedYes


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