Pulmonary hypertension in congenital diaphragmatic hernia: Antenatal prediction and impact on neonatal mortality

David Basurto, Francesca Maria Russo, Ioannis Papastefanou, Emma Bredaki, Karel Allegaert, Africa Pertierra, Anne Debeer, Luc De Catte, Liesbeth Lewi, Roland Devlieger, Paolo De Coppi, Eduard Gratacos, Olga Gomez, Jan Deprest*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)
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Objective: To determine the prevalence of pulmonary hypertension (PAH) in left-sided congenital diaphragmatic hernia (CDH); how we could predict it; and how PAH contributed to the model for mortality prediction. Study Design: Retrospective analysis in three European centers. The primary outcome was the presence of PAH on postnatal day (d) 1, 7, and at discharge. Studied predictors of PAH were: observed/expected-lung/head-ratio (o/e LHR), liver-herniation, fetoscopic endoluminal tracheal occlusion (FETO), and gestational age (GA) at delivery. The combined effect of pre- and postnatal variables on mortality was modeled by Cox regression. Results: Of the 197 neonates, 56 (28.4%) died. At d1, 67.5% (133/197) had PAH and 61.9% (101/163) by d7. Overall, 6.4% (9/141) had PAH at discharge. At d1, o/e LHR (odds ratio (OR) 0.96) and FETO (OR 2.99) independently correlated to PAH (areas under the curve [AUC]: 0.74). At d7, PAH significantly correlated only with the use of FETO (OR 3.9; AUC: 0.65). None were significant for PAH at discharge. Combining the occurrence of PAH with antenatal biomarkers improved mortality prediction (p = 0.02), in a model including o/e LHR (HR: 0.94), FETO (HR: 0.35), liver herniation (HR: 16.78), and PAH (HR: 15.95). Conclusions: Antenatal prediction of PAH was only moderate. The postnatal occurrence of PAH further increases the risk of death. Whereas this may be used to counsel parents in the postnatal period, our study demonstrates there is a need to find more accurate antenatal predictors for PAH.

Original languageEnglish
Pages (from-to)1303-1311
Number of pages9
JournalPrenatal Diagnosis
Issue number10
Publication statusPublished - 7 Jul 2022

Bibliographical note

Funding information
KU Leuven; Erasmus + Programme of the
European Union, Grant/Award Number: 2013‐
0040; Fonds voor Wetenschappelijk
Onderzoek, Grant/Award Number:
1804718N; National Institute for Health
Research Applied Research Collaboration
South West Peninsula, Grant/Award Number:

Publisher Copyright:
© 2022 John Wiley & Sons Ltd.


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