Qualitative agreement and diagnostic performance of arterial spin labelling MRI and FDG PET-CT in suspected early-stage dementia: Comparison of arterial spin labelling MRI and FDG PET-CT in suspected dementia

Kathleen Weyts*, Meike Vernooij, Rebecca Steketee, Roelf Valkema, Marion Smits

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)
10 Downloads (Pure)

Abstract

18FDG PET-CT is useful for early and differential diagnosis of dementia. ASL-MRI seems an attractive alternative. Visual agreement was calculated in 21 brain regions bilaterally in 9/11 patients with suspected early-stage dementia, excluding 2 patients due to ASL-MRI motion artefacts. Overall gross agreement was almost perfect and identical between and within modalities (κ=0.85-0.86, p<0.05). Intermodality regional agreement was variable, moderate (κ=0,56 in posterior cingulate) to perfect (including in precuneus), not different from intramodality agreement. Diagnostic accuracy was 5/9 (56%) for ASL-MRI and 7/9 (78%) for FDG PETCT. (p=0.31). Clinical experience and optimisation may further improve ASL-MRI's performance.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalClinical Imaging
Volume45
Early online date25 May 2017
DOIs
Publication statusPublished - 1 Sep 2017

Bibliographical note

Copyright © 2017 Elsevier Inc. All rights reserved.

Fingerprint

Dive into the research topics of 'Qualitative agreement and diagnostic performance of arterial spin labelling MRI and FDG PET-CT in suspected early-stage dementia: Comparison of arterial spin labelling MRI and FDG PET-CT in suspected dementia'. Together they form a unique fingerprint.

Cite this