Qualitative agreement and diagnostic performance of arterial spin labelling MRI and FDG PET-CT in suspected early-stage dementia: Comparison of arterial spin labelling MRI and FDG PET-CT in suspected dementia

Kathleen Weyts; Meike Vernooij; Rebecca Steketee; Roelf Valkema; Marion Smits

doi:10.1016/j.clinimag.2017.05.008

Qualitative agreement and diagnostic performance of arterial spin labelling MRI and FDG PET-CT in suspected early-stage dementia: Comparison of arterial spin labelling MRI and FDG PET-CT in suspected dementia

Kathleen Weyts^*, Meike Vernooij, Rebecca Steketee, Roelf Valkema, Marion Smits

^*Corresponding author for this work

Radiology & Nuclear Medicine

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Scopus)

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Abstract

18FDG PET-CT is useful for early and differential diagnosis of dementia. ASL-MRI seems an attractive alternative. Visual agreement was calculated in 21 brain regions bilaterally in 9/11 patients with suspected early-stage dementia, excluding 2 patients due to ASL-MRI motion artefacts. Overall gross agreement was almost perfect and identical between and within modalities (κ=0.85-0.86, p<0.05). Intermodality regional agreement was variable, moderate (κ=0,56 in posterior cingulate) to perfect (including in precuneus), not different from intramodality agreement. Diagnostic accuracy was 5/9 (56%) for ASL-MRI and 7/9 (78%) for FDG PETCT. (p=0.31). Clinical experience and optimisation may further improve ASL-MRI's performance.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Clinical Imaging
Volume	45
Early online date	25 May 2017
DOIs	https://doi.org/10.1016/j.clinimag.2017.05.008
Publication status	Published - 1 Sep 2017

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title = "Qualitative agreement and diagnostic performance of arterial spin labelling MRI and FDG PET-CT in suspected early-stage dementia: Comparison of arterial spin labelling MRI and FDG PET-CT in suspected dementia",

abstract = "18FDG PET-CT is useful for early and differential diagnosis of dementia. ASL-MRI seems an attractive alternative. Visual agreement was calculated in 21 brain regions bilaterally in 9/11 patients with suspected early-stage dementia, excluding 2 patients due to ASL-MRI motion artefacts. Overall gross agreement was almost perfect and identical between and within modalities (κ=0.85-0.86, p<0.05). Intermodality regional agreement was variable, moderate (κ=0,56 in posterior cingulate) to perfect (including in precuneus), not different from intramodality agreement. Diagnostic accuracy was 5/9 (56%) for ASL-MRI and 7/9 (78%) for FDG PETCT. (p=0.31). Clinical experience and optimisation may further improve ASL-MRI's performance.",

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Qualitative agreement and diagnostic performance of arterial spin labelling MRI and FDG PET-CT in suspected early-stage dementia : Comparison of arterial spin labelling MRI and FDG PET-CT in suspected dementia. / Weyts, Kathleen; Vernooij, Meike ; Steketee, Rebecca et al.

In: Clinical Imaging, Vol. 45, 01.09.2017, p. 1-7.

Research output: Contribution to journal › Article › Academic › peer-review

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