TY - JOUR
T1 - Quality of Life and Kidney Function in Older Adults
T2 - Prospective Data of the SCOPE Study
AU - Artzi-Medvedik, Rada
AU - Kob, Robert
AU - Screening for CKD among Older People across Europe (SCOPE) study investigators
AU - Di Rosa, Mirko
AU - Lattanzio, Fabrizia
AU - Corsonello, Andrea
AU - Yehoshua, Ilan
AU - Roller-Wirnsberger, Regina E.
AU - Wirnsberger, Gerhard H.
AU - Mattace-Raso, Francesco U.S.
AU - Tap, Lisanne
AU - Gil, Pedro G.
AU - Formiga, Francesc
AU - Moreno-González, Rafael
AU - Kostka, Tomasz
AU - Guligowska, Agnieszka
AU - Ärnlöv, Johan
AU - Carlsson, Axel C.
AU - Freiberger, Ellen
AU - Melzer, Itshak
N1 - Funding Information:
The work reported in this publication was supported by the European Union Horizon 2020 program, under the Grant Agreement no. 634869, following a peer review process.
Publisher Copyright:
© 2023 by the authors.
PY - 2023/6/9
Y1 - 2023/6/9
N2 - A longitudinal alteration in health-related quality of life (HRQoL) over a two-year period and its association with early-stage chronic kidney disease (CKD) progression was investigated among 1748 older adults (>75 years). HRQoL was measured by the Euro-Quality of Life Visual Analog Scale (EQ-VAS) at baseline and at one and two years after recruitment. A full comprehensive geriatric assessment was performed, including sociodemographic and clinical characteristics, the Geriatric Depression Scale-Short Form (GDS-SF), Short Physical Performance Battery (SPPB), and estimated glomerular filtration rate (eGFR). The association between EQ-VAS decline and covariates was investigated by multivariable analyses. A total of 41% of the participants showed EQ-VAS decline, and 16.3% showed kidney function decline over the two-year follow-up period. Participants with EQ-VAS decline showed an increase in GDS-SF scores and a greater decline in SPPB scores. The logistic regression analyses showed no contribution of a decrease in kidney function on EQ-VAS decline in the early stages of CKD. However, older adults with a greater GDS-SF score were more likely to present EQ-VAS decline over time, whereas an increase in the SPPB scores was associated with less EQ-VAS decline. This finding should be considered in clinical practice and when HRQoL is used to evaluate health interventions among older adults.
AB - A longitudinal alteration in health-related quality of life (HRQoL) over a two-year period and its association with early-stage chronic kidney disease (CKD) progression was investigated among 1748 older adults (>75 years). HRQoL was measured by the Euro-Quality of Life Visual Analog Scale (EQ-VAS) at baseline and at one and two years after recruitment. A full comprehensive geriatric assessment was performed, including sociodemographic and clinical characteristics, the Geriatric Depression Scale-Short Form (GDS-SF), Short Physical Performance Battery (SPPB), and estimated glomerular filtration rate (eGFR). The association between EQ-VAS decline and covariates was investigated by multivariable analyses. A total of 41% of the participants showed EQ-VAS decline, and 16.3% showed kidney function decline over the two-year follow-up period. Participants with EQ-VAS decline showed an increase in GDS-SF scores and a greater decline in SPPB scores. The logistic regression analyses showed no contribution of a decrease in kidney function on EQ-VAS decline in the early stages of CKD. However, older adults with a greater GDS-SF score were more likely to present EQ-VAS decline over time, whereas an increase in the SPPB scores was associated with less EQ-VAS decline. This finding should be considered in clinical practice and when HRQoL is used to evaluate health interventions among older adults.
UR - http://www.scopus.com/inward/record.url?scp=85163761660&partnerID=8YFLogxK
U2 - 10.3390/jcm12123959
DO - 10.3390/jcm12123959
M3 - Article
C2 - 37373653
AN - SCOPUS:85163761660
SN - 2077-0383
VL - 12
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
IS - 12
M1 - 3959
ER -