Quality of Life and Kidney Function in Older Adults: Prospective Data of the SCOPE Study

Rada Artzi-Medvedik, Robert Kob, on behalf of the SCOPE Investigators, Mirko Di Rosa, Fabrizia Lattanzio, Andrea Corsonello, Ilan Yehoshua, Regina E. Roller-Wirnsberger, Gerhard H. Wirnsberger, Francesco U.S. Mattace-Raso, Lisanne Tap, Pedro G. Gil, Francesc Formiga, Rafael Moreno-González, Tomasz Kostka, Agnieszka Guligowska, Johan Ärnlöv, Axel C. Carlsson, Ellen Freiberger*, Itshak Melzer*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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A longitudinal alteration in health-related quality of life (HRQoL) over a two-year period and its association with early-stage chronic kidney disease (CKD) progression was investigated among 1748 older adults (>75 years). HRQoL was measured by the Euro-Quality of Life Visual Analog Scale (EQ-VAS) at baseline and at one and two years after recruitment. A full comprehensive geriatric assessment was performed, including sociodemographic and clinical characteristics, the Geriatric Depression Scale-Short Form (GDS-SF), Short Physical Performance Battery (SPPB), and estimated glomerular filtration rate (eGFR). The association between EQ-VAS decline and covariates was investigated by multivariable analyses. A total of 41% of the participants showed EQ-VAS decline, and 16.3% showed kidney function decline over the two-year follow-up period. Participants with EQ-VAS decline showed an increase in GDS-SF scores and a greater decline in SPPB scores. The logistic regression analyses showed no contribution of a decrease in kidney function on EQ-VAS decline in the early stages of CKD. However, older adults with a greater GDS-SF score were more likely to present EQ-VAS decline over time, whereas an increase in the SPPB scores was associated with less EQ-VAS decline. This finding should be considered in clinical practice and when HRQoL is used to evaluate health interventions among older adults.

Original languageEnglish
Article number3959
JournalJournal of Clinical Medicine
Issue number12
Publication statusPublished - 9 Jun 2023

Bibliographical note

Funding Information:
The work reported in this publication was supported by the European Union Horizon 2020 program, under the Grant Agreement no. 634869, following a peer review process.

Publisher Copyright:
© 2023 by the authors.


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