Quality of life in patients with a perineal hernia

Saskia I. Kreisel; Sarah Sharabiany; Joost Rothbarth; Roel Hompes; Gijsbert D. Musters; Pieter J. Tanis

doi:10.1016/j.ejso.2023.107114

Quality of life in patients with a perineal hernia

Saskia I. Kreisel
, Sarah Sharabiany
, Joost Rothbarth
, Roel Hompes
, Gijsbert D. Musters
, Pieter J. Tanis^*

^*Corresponding author for this work

Surgery

University of Amsterdam
Amsterdam UMC
Erasmus University Rotterdam
Cancer Center Amsterdam (CCA)

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

65 Downloads (Pure)

Abstract

Introduction:

Patients who develop a perineal hernia after abdominoperineal resection may experience discomfort during daily activities and urogenital dysfunction, but the impact on quality of life has never been formally assessed.

Materials and methods:

Patients who underwent abdominoperineal resection for rectal cancer between 2014 and 2022 in two prospective multicenter trials were included. Primary outcome was defined as median overall scores or scores on functional and symptom scales of the following quality of life questionnaires: 5-level version of the 5-dimensional EuroQol, Short Form-36, and European Organization for Research and Treatment of Cancer QoL Questionnaire Colorectal cancer 29 and 30, Urogenital Distress Inventory-6, Incontinence Impact Questionnaire-7.

Results:

Questionnaires were available in 27 patients with a perineal hernia and 62 patients without a perineal hernia. The 5-dimensional EuroQol score was significantly lower in patients with a perineal hernia (83 vs 87, p = 0.048), which implies a reduced level of functioning. The median scores of pain-specific domains were significantly worse in patients with a perineal hernia as measured by the SF-36 (78 vs. 90, p = 0.006), the EORTC-CR29 (17 vs. 11, p=<0.001) and EORTC-C30 (17 vs. 0, p = 0.019). Also, significantly worse physical (73 vs. 100, p = 0.049) and emotional (83 vs. 100, p = 0.048) functioning based on EORTC-C30 was observed among those patients. Minimally important differences were found for role, physical and social functioning of the SF-36 and EORTC-C30. The urological function did not differ between the groups.

Conclusion:

A symptomatic perineal hernia can significantly worsen quality of life on several domains, indicating the severity of this complication.

Original language	English
Article number	107114
Number of pages	5
Journal	European Journal of Surgical Oncology
Volume	49
Issue number	12
DOIs	https://doi.org/10.1016/j.ejso.2023.107114
Publication status	Published - Dec 2023

Bibliographical note

Funding Information:
The data used in this cohort study was retrospectively obtained from the databases of two prospective trials which were funded by by LifeCell, an Allergan Company (NL42094.018.12), and by the Dutch Cancer Society (‘KWF Kankerbestrijding’) (NL65461.180.18). These funding sources did not influence the study designs nor the results of the trails.The data used in this cohort study was retrospectively obtained from the databases of two prospective trials which were funded by LifeCell, an Allergan Company (NL42094.018.12), and by the Dutch Cancer Society (‘KWF Kankerbestrijding’) (NL65461.180.18).The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: P.J. Tanis reports financial support was provided by Dutch Cancer Society. P.J. Tanis reports financial support was provided by LifeCell Corp.

Funding Information:
The data used in this cohort study was retrospectively obtained from the databases of two prospective trials which were funded by by LifeCell, an Allergan Company (NL42094.018.12), and by the Dutch Cancer Society (‘KWF Kankerbestrijding’) ( NL65461.180.18 ). These funding sources did not influence the study designs nor the results of the trails.

Funding Information:
The data used in this cohort study was retrospectively obtained from the databases of two prospective trials which were funded by LifeCell, an Allergan Company (NL42094.018.12), and by the Dutch Cancer Society (‘KWF Kankerbestrijding’) ( NL65461.180.18 ).

Publisher Copyright:
© 2023 The Authors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.ejso.2023.107114

Quality of life in patients with a perineal herniaFinal published version, 393 KBLicence: CC BY-NC-ND

Cite this

@article{70236766f67b4386b7f5c8bdf4fed2ae,

title = "Quality of life in patients with a perineal hernia",

abstract = "Introduction: Patients who develop a perineal hernia after abdominoperineal resection may experience discomfort during daily activities and urogenital dysfunction, but the impact on quality of life has never been formally assessed. Materials and methods: Patients who underwent abdominoperineal resection for rectal cancer between 2014 and 2022 in two prospective multicenter trials were included. Primary outcome was defined as median overall scores or scores on functional and symptom scales of the following quality of life questionnaires: 5-level version of the 5-dimensional EuroQol, Short Form-36, and European Organization for Research and Treatment of Cancer QoL Questionnaire Colorectal cancer 29 and 30, Urogenital Distress Inventory-6, Incontinence Impact Questionnaire-7. Results: Questionnaires were available in 27 patients with a perineal hernia and 62 patients without a perineal hernia. The 5-dimensional EuroQol score was significantly lower in patients with a perineal hernia (83 vs 87, p = 0.048), which implies a reduced level of functioning. The median scores of pain-specific domains were significantly worse in patients with a perineal hernia as measured by the SF-36 (78 vs. 90, p = 0.006), the EORTC-CR29 (17 vs. 11, p=<0.001) and EORTC-C30 (17 vs. 0, p = 0.019). Also, significantly worse physical (73 vs. 100, p = 0.049) and emotional (83 vs. 100, p = 0.048) functioning based on EORTC-C30 was observed among those patients. Minimally important differences were found for role, physical and social functioning of the SF-36 and EORTC-C30. The urological function did not differ between the groups. Conclusion: A symptomatic perineal hernia can significantly worsen quality of life on several domains, indicating the severity of this complication.",

author = "Kreisel, \{Saskia I.\} and Sarah Sharabiany and Joost Rothbarth and Roel Hompes and Musters, \{Gijsbert D.\} and Tanis, \{Pieter J.\}",

note = "Funding Information: The data used in this cohort study was retrospectively obtained from the databases of two prospective trials which were funded by by LifeCell, an Allergan Company (NL42094.018.12), and by the Dutch Cancer Society ({\textquoteleft}KWF Kankerbestrijding{\textquoteright}) (NL65461.180.18). These funding sources did not influence the study designs nor the results of the trails.The data used in this cohort study was retrospectively obtained from the databases of two prospective trials which were funded by LifeCell, an Allergan Company (NL42094.018.12), and by the Dutch Cancer Society ({\textquoteleft}KWF Kankerbestrijding{\textquoteright}) (NL65461.180.18).The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: P.J. Tanis reports financial support was provided by Dutch Cancer Society. P.J. Tanis reports financial support was provided by LifeCell Corp. Funding Information: The data used in this cohort study was retrospectively obtained from the databases of two prospective trials which were funded by by LifeCell, an Allergan Company (NL42094.018.12), and by the Dutch Cancer Society ({\textquoteleft}KWF Kankerbestrijding{\textquoteright}) ( NL65461.180.18 ). These funding sources did not influence the study designs nor the results of the trails. Funding Information: The data used in this cohort study was retrospectively obtained from the databases of two prospective trials which were funded by LifeCell, an Allergan Company (NL42094.018.12), and by the Dutch Cancer Society ({\textquoteleft}KWF Kankerbestrijding{\textquoteright}) ( NL65461.180.18 ). Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = dec,

doi = "10.1016/j.ejso.2023.107114",

language = "English",

volume = "49",

journal = "European Journal of Surgical Oncology",

issn = "0748-7983",

number = "12",

}

TY - JOUR

T1 - Quality of life in patients with a perineal hernia

AU - Kreisel, Saskia I.

AU - Sharabiany, Sarah

AU - Rothbarth, Joost

AU - Hompes, Roel

AU - Musters, Gijsbert D.

AU - Tanis, Pieter J.

N1 - Funding Information: The data used in this cohort study was retrospectively obtained from the databases of two prospective trials which were funded by by LifeCell, an Allergan Company (NL42094.018.12), and by the Dutch Cancer Society (‘KWF Kankerbestrijding’) (NL65461.180.18). These funding sources did not influence the study designs nor the results of the trails.The data used in this cohort study was retrospectively obtained from the databases of two prospective trials which were funded by LifeCell, an Allergan Company (NL42094.018.12), and by the Dutch Cancer Society (‘KWF Kankerbestrijding’) (NL65461.180.18).The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: P.J. Tanis reports financial support was provided by Dutch Cancer Society. P.J. Tanis reports financial support was provided by LifeCell Corp. Funding Information: The data used in this cohort study was retrospectively obtained from the databases of two prospective trials which were funded by by LifeCell, an Allergan Company (NL42094.018.12), and by the Dutch Cancer Society (‘KWF Kankerbestrijding’) ( NL65461.180.18 ). These funding sources did not influence the study designs nor the results of the trails. Funding Information: The data used in this cohort study was retrospectively obtained from the databases of two prospective trials which were funded by LifeCell, an Allergan Company (NL42094.018.12), and by the Dutch Cancer Society (‘KWF Kankerbestrijding’) ( NL65461.180.18 ). Publisher Copyright: © 2023 The Authors

PY - 2023/12

Y1 - 2023/12

N2 - Introduction: Patients who develop a perineal hernia after abdominoperineal resection may experience discomfort during daily activities and urogenital dysfunction, but the impact on quality of life has never been formally assessed. Materials and methods: Patients who underwent abdominoperineal resection for rectal cancer between 2014 and 2022 in two prospective multicenter trials were included. Primary outcome was defined as median overall scores or scores on functional and symptom scales of the following quality of life questionnaires: 5-level version of the 5-dimensional EuroQol, Short Form-36, and European Organization for Research and Treatment of Cancer QoL Questionnaire Colorectal cancer 29 and 30, Urogenital Distress Inventory-6, Incontinence Impact Questionnaire-7. Results: Questionnaires were available in 27 patients with a perineal hernia and 62 patients without a perineal hernia. The 5-dimensional EuroQol score was significantly lower in patients with a perineal hernia (83 vs 87, p = 0.048), which implies a reduced level of functioning. The median scores of pain-specific domains were significantly worse in patients with a perineal hernia as measured by the SF-36 (78 vs. 90, p = 0.006), the EORTC-CR29 (17 vs. 11, p=<0.001) and EORTC-C30 (17 vs. 0, p = 0.019). Also, significantly worse physical (73 vs. 100, p = 0.049) and emotional (83 vs. 100, p = 0.048) functioning based on EORTC-C30 was observed among those patients. Minimally important differences were found for role, physical and social functioning of the SF-36 and EORTC-C30. The urological function did not differ between the groups. Conclusion: A symptomatic perineal hernia can significantly worsen quality of life on several domains, indicating the severity of this complication.

AB - Introduction: Patients who develop a perineal hernia after abdominoperineal resection may experience discomfort during daily activities and urogenital dysfunction, but the impact on quality of life has never been formally assessed. Materials and methods: Patients who underwent abdominoperineal resection for rectal cancer between 2014 and 2022 in two prospective multicenter trials were included. Primary outcome was defined as median overall scores or scores on functional and symptom scales of the following quality of life questionnaires: 5-level version of the 5-dimensional EuroQol, Short Form-36, and European Organization for Research and Treatment of Cancer QoL Questionnaire Colorectal cancer 29 and 30, Urogenital Distress Inventory-6, Incontinence Impact Questionnaire-7. Results: Questionnaires were available in 27 patients with a perineal hernia and 62 patients without a perineal hernia. The 5-dimensional EuroQol score was significantly lower in patients with a perineal hernia (83 vs 87, p = 0.048), which implies a reduced level of functioning. The median scores of pain-specific domains were significantly worse in patients with a perineal hernia as measured by the SF-36 (78 vs. 90, p = 0.006), the EORTC-CR29 (17 vs. 11, p=<0.001) and EORTC-C30 (17 vs. 0, p = 0.019). Also, significantly worse physical (73 vs. 100, p = 0.049) and emotional (83 vs. 100, p = 0.048) functioning based on EORTC-C30 was observed among those patients. Minimally important differences were found for role, physical and social functioning of the SF-36 and EORTC-C30. The urological function did not differ between the groups. Conclusion: A symptomatic perineal hernia can significantly worsen quality of life on several domains, indicating the severity of this complication.

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DO - 10.1016/j.ejso.2023.107114

M3 - Article

C2 - 37839295

AN - SCOPUS:85173935478

SN - 0748-7983

VL - 49

JO - European Journal of Surgical Oncology

JF - European Journal of Surgical Oncology

IS - 12

M1 - 107114

ER -

Quality of life in patients with a perineal hernia

Abstract

Bibliographical note

UN SDGs

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