TY - GEN
T1 - Quantification of DCE-MRI
T2 - 2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012
AU - Bol, Karin
AU - Haeck, Joost C.
AU - Alic, Lejla
AU - Niessen, Wiro J.
AU - De Jong, Marion
AU - Bernsen, Monique
AU - Veenland, Jifke F.
PY - 2012
Y1 - 2012
N2 - Three different DCE-MRI quantification methods: model-free-based, compartment-model-based and principal component analysis, are compared by evaluating parameter maps for histological defined volumes of vital and non-vital tumor tissue. To obtain an accurate spatial correspondence between histology and DCE-MRI, a two-step registration process was used involving dense histological sampling, a reference plane and an intermediate ex vivo MRI. Results show that the model-free parameter washout and the second principal component score can adequately separate vital from non-vital tumor tissue, with an accuracy of respectively 99.2% and 99.7%. The other model-free parameters and the compartment-model-based Ktrans show some overlap in values between vital and non-vital tissue. The first, third and fourth pc-score have limited discriminative power.
AB - Three different DCE-MRI quantification methods: model-free-based, compartment-model-based and principal component analysis, are compared by evaluating parameter maps for histological defined volumes of vital and non-vital tumor tissue. To obtain an accurate spatial correspondence between histology and DCE-MRI, a two-step registration process was used involving dense histological sampling, a reference plane and an intermediate ex vivo MRI. Results show that the model-free parameter washout and the second principal component score can adequately separate vital from non-vital tumor tissue, with an accuracy of respectively 99.2% and 99.7%. The other model-free parameters and the compartment-model-based Ktrans show some overlap in values between vital and non-vital tissue. The first, third and fourth pc-score have limited discriminative power.
UR - https://www.scopus.com/pages/publications/84864863391
U2 - 10.1109/ISBI.2012.6235737
DO - 10.1109/ISBI.2012.6235737
M3 - Conference proceeding
AN - SCOPUS:84864863391
SN - 9781457718588
T3 - Proceedings - International Symposium on Biomedical Imaging
SP - 1044
EP - 1047
BT - 2012 9th IEEE International Symposium on Biomedical Imaging
Y2 - 2 May 2012 through 5 May 2012
ER -