Quantification of Intracranial Aneurysm Morphodynamics from ECG-gated CT Angiography

Azadeh Firouzian, Rashindra Manniesing, Coert Metz, Roelof Risselada, Stefan Klein, Fop Kooten, MCJM Sturkenboom, Aad van der Lugt, Wiro Niessen

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)


Rationale and Objectives: Aneurysm morphodynamics is potentially relevant for assessing aneurysm rupture risk. A method is proposed for automated quantification and visualization of intracranial aneurysm morphodynamics from electrocardiogram (ECG)-gated computed tomography angiography (CTA) data. Materials and Methods: A prospective study was performed in 19 aneurysms from 14 patients with diagnostic workup for recently discovered aneurysms (n = 15) or follow-up of untreated known aneurysms (n = 4). The study was approved by the Institutional Review Board of the hospital and written informed consent was obtained from each patient. An image postprocessing method was developed for quantifying aneurysm volume changes and visualizing local displacement of the aneurysmal wall over a heart cyc Results: Pulsation of the aneurysm and its surrounding vasculature during the heart cycle could be assessed from ECG-gated CTA data. The percentage aneurysmal volume change ranged from 3% to 18%. Conclusion: ECG-gated CTA can be used to study morphodynamics of intracranial aneurysms. The proposed image analysis method is capable of quantifying the volume changes and visualizing local displacement of the vascular structures over the cardiac cycle.
Original languageUndefined/Unknown
Pages (from-to)52-58
Number of pages7
JournalAcademic Radiology
Issue number1
Publication statusPublished - 2013

Research programs

  • EMC COEUR-09
  • EMC NIHES-03-30-01
  • EMC NIHES-03-30-03

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