Quantitative MRI protocol and decision model for a 'one stop shop' early-stage Parkinsonism diagnosis: Study design

Samy Abo Seada; Anke W van der Eerden; Agnita J W Boon; Juan A Hernandez-Tamames

doi:10.1016/j.nicl.2023.103506

Quantitative MRI protocol and decision model for a 'one stop shop' early-stage Parkinsonism diagnosis: Study design

Samy Abo Seada
, Anke W van der Eerden
, Agnita J W Boon
, Juan A Hernandez-Tamames^*

^*Corresponding author for this work

Technische Universiteit Delft

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

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Abstract

Differentiating among early-stage parkinsonisms is a challenge in clinical practice. Quantitative MRI can aid the diagnostic process, but studies with singular MRI techniques have had limited success thus far. Our objective is to develop a multi-modal MRI method for this purpose. In this review we describe existing methods and present a dedicated quantitative MRI protocol, a decision model and a study design to validate our approach ahead of a pilot study. We present example imaging data from patients and a healthy control, which resemble related literature.

Original language	English
Article number	103506
Number of pages	12
Journal	NeuroImage: Clinical
Volume	39
DOIs	https://doi.org/10.1016/j.nicl.2023.103506
Publication status	Published - Jan 2023

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10.1016/j.nicl.2023.103506Licence: CC BY-NC-ND

Quantitative MRI protocol and decision model for a ‘one stop shop’ early-stage Parkinsonism diagnosisFinal published version, 6.66 MBLicence: CC BY-NC-ND

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AU - Hernandez-Tamames, Juan A

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AB - Differentiating among early-stage parkinsonisms is a challenge in clinical practice. Quantitative MRI can aid the diagnostic process, but studies with singular MRI techniques have had limited success thus far. Our objective is to develop a multi-modal MRI method for this purpose. In this review we describe existing methods and present a dedicated quantitative MRI protocol, a decision model and a study design to validate our approach ahead of a pilot study. We present example imaging data from patients and a healthy control, which resemble related literature.

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Quantitative MRI protocol and decision model for a 'one stop shop' early-stage Parkinsonism diagnosis: Study design

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