TY - JOUR
T1 - Rac-dependent and -independent pathways mediate growth factor-induced Ca2+ influx
AU - Peppelenbosch, Maikel P.
AU - Tertoolen, Leon G.J.
AU - De Vries-Smits, Alida M.M.
AU - Qiu, Rong Guo
AU - M'Rabet, Laura
AU - Symons, Marc H.
AU - De Laat, Siegfried W.
AU - Bos, Johannes L.
PY - 1996/4/5
Y1 - 1996/4/5
N2 - We report that expressing interfering mutants of the small Ras-related GTPase Rac, using either recombinant vaccinia virus or stable DNA transfection, eliminates epidermal growth factor-induced Ca2+ signaling, without affecting Ca2+ mobilization or influx from G protein-coupled receptors. Platelet-derived growth factor-dependent Ca2+ influx, however, is only partly sensitive to dominant negative Rac proteins. Thus, whereas epidermal growth factor-induced Ca2+ influx is completely mediated by Rac proteins, platelet-derived growth factor-induced Ca2+ influx involves Rac-dependent and -independent signaling pathways.
AB - We report that expressing interfering mutants of the small Ras-related GTPase Rac, using either recombinant vaccinia virus or stable DNA transfection, eliminates epidermal growth factor-induced Ca2+ signaling, without affecting Ca2+ mobilization or influx from G protein-coupled receptors. Platelet-derived growth factor-dependent Ca2+ influx, however, is only partly sensitive to dominant negative Rac proteins. Thus, whereas epidermal growth factor-induced Ca2+ influx is completely mediated by Rac proteins, platelet-derived growth factor-induced Ca2+ influx involves Rac-dependent and -independent signaling pathways.
UR - http://www.scopus.com/inward/record.url?scp=0029924236&partnerID=8YFLogxK
U2 - 10.1074/jbc.271.14.7883
DO - 10.1074/jbc.271.14.7883
M3 - Article
C2 - 8626463
AN - SCOPUS:0029924236
SN - 0021-9258
VL - 271
SP - 7883
EP - 7886
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 14
ER -