Rac-dependent and -independent pathways mediate growth factor-induced Ca2+ influx

Maikel P. Peppelenbosch, Leon G.J. Tertoolen, Alida M.M. De Vries-Smits, Rong Guo Qiu, Laura M'Rabet, Marc H. Symons, Siegfried W. De Laat, Johannes L. Bos*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

42 Citations (Scopus)
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Abstract

We report that expressing interfering mutants of the small Ras-related GTPase Rac, using either recombinant vaccinia virus or stable DNA transfection, eliminates epidermal growth factor-induced Ca2+ signaling, without affecting Ca2+ mobilization or influx from G protein-coupled receptors. Platelet-derived growth factor-dependent Ca2+ influx, however, is only partly sensitive to dominant negative Rac proteins. Thus, whereas epidermal growth factor-induced Ca2+ influx is completely mediated by Rac proteins, platelet-derived growth factor-induced Ca2+ influx involves Rac-dependent and -independent signaling pathways.

Original languageEnglish
Pages (from-to)7883-7886
Number of pages4
JournalJournal of Biological Chemistry
Volume271
Issue number14
DOIs
Publication statusPublished - 5 Apr 1996
Externally publishedYes

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