Radiofrequency Ablation for Benign Symptomatic Thyroid Nodules in the Netherlands: Successful Introduction of a Minimally Invasive Treatment Option Improving Quality of Life

Ivona Lončar*, Sam P.J. van Dijk, Evert F.S. van Velsen, Steven E. Buijk, Nienke D. Niemeijer, Cornelis J. Veeken, Erik M. von Meyenfeldt, Wouter Dinkelaar, Gaston J.H. Franssen, Robin P. Peeters, Elske T. Massolt, Adriaan Moelker, Tessa M. van Ginhoven

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Purpose: To determine whether adoption of radiofrequency (RF) ablation in patients with symptomatic benign thyroid nodules (SBTNs) in a Dutch regional thyroid network resulted in clinical success and improvement in health-related and thyroid-related quality of life (QoL). Materials and Methods: The eligibility criteria for RF ablation were as follows: (a) nodule size between 2.0 and 5.0 cm, (b) solid component >20%; (c) benign cytology in 2 separate cytological assessments, and (d) symptoms unequivocally related to mechanical compression. The primary end point of this study was volume reduction 1 year after ablation. The secondary outcomes were health-related and thyroid-related QoL, measured using the short form health survey questionnaire (SF-36) and thyroid-specific patient-reported outcome questionnaire (ThyPRO-39), respectively, as well as adverse event rates. Results: A total of 72 SBTNs in 67 patients were included. Median age was 50.0 (interquartile range, 41.0–56.0) years, and 91.0% were women. The median volume reduction at 6 weeks, 6 months, 1 year, 2 years, and 3 years was 51.0%, 63.9%, 65.2%, 81.3%, and 90.3%, respectively. The patients showed a significant improvement on the SF-36 physical component scale and ThyPRO-39 overall QoL-impact scale. An absolute improvement was seen in goiter and cosmetic complaints, determined using ThyPRO-39. The overall adverse event rate was 9.0%, of which 4.5% were considered major. Conclusions: RF ablation is an effective treatment option for SBTNs, with a significant volume reduction and improvement in health-related and thyroid-related QoL.

Original languageEnglish
Pages (from-to)530-537.e1
JournalJournal of Vascular and Interventional Radiology
Volume33
Issue number5
DOIs
Publication statusAccepted/In press - 2022

Bibliographical note

Funding Information:
We would like to thank Dr A. J. R?ten-Budde for her help with the statistical analyses of this manuscript.

Publisher Copyright:
© 2022 SIR

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