Randomized study designs for lifestyle interventions: a tutorial

John Younge, Tessa Pasmooij, R Freak-Poli, Jolien Roos - Hesselink, Myriam Hunink

Research output: Contribution to journalArticleAcademicpeer-review

35 Citations (Scopus)


Unhealthy lifestyle behaviours are considered modifiable risk factors for many diseases. Lifestyle interventions that target these behaviours need rigorous evaluation to assess their effectiveness. The randomized controlled trial is the study design of choice when it comes to the evaluation of interventions. However, lifestyle interventions are often complex and subject to several important issues, such as patient preference and non-adherence, that may threaten the internal and external validity of studies. There is a strong demand for high-quality randomized controlled trials of interventions that promote healthy lifestyle behaviours. With this tutorial we aim to provide guidance in the choice of an optimal randomized controlled trial design in future trials of lifestyle interventions.
Original languageUndefined/Unknown
Pages (from-to)2006-2019
Number of pages14
JournalInternational Journal of Epidemiology
Issue number6
Publication statusPublished - 2015

Research programs

  • EMC COEUR-09
  • EMC NIHES-01-64-03
  • EMC NIHES-03-30-02

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