Randomized study to assess the effect of thrombus aspiration on flow area in patients with ST-elevation myocardial infarction: an optical frequency domain imaging study-TROFI trial

Yoshinobu Onuma, L Thuesen, Robert Jan van Geuns, M van der Ent, S Desch, J Fajadet, E Christiansen, P Smits, NR Holm, Evelyn Regar, Nicolas van Mieghem, V Borovicanin, D Paunovic, K Senshu, Gerrit-anne Es, Takashi Muramatsu, IS Lee, G Schuler, Felix Zijlstra, Hector Garcia GarciaPWJC (Patrick) Serruys

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Abstract

Aims Primary percutaneous coronary intervention (PPCI) with thrombectomy (TB) seems to reduce the thrombus burden, resulting in a larger flow area as measured with optical frequency domain imaging (OFDI). Methods and results In a multi-centre study, 141 patients with ST elevation myocardial infarction,12 h from onset were randomized to either PPCI with TB using an Eliminate catheter (TB: n = 71) or without TB (non-TB: n = 70), having operators blinded for the OFDI results. The primary endpoint was minimum flow area (MinFA) post-procedure assessed by OFDI, defined as: [stent area + incomplete stent apposition (ISA) area] - (intraluminal defect + tissue prolapse area). Sample size was based on the Conclusion PPCI with TB was associated with a similar flow area as well as stent area to PPCI without TB.
Original languageUndefined/Unknown
Pages (from-to)1050-1060b
JournalEuropean Heart Journal
Volume34
Issue number14
DOIs
Publication statusPublished - 2013

Research programs

  • EMC COEUR-09

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