Randomized study to assess the effect of thrombus aspiration on flow area in patients with ST-elevation myocardial infarction: an optical frequency domain imaging study-TROFI trial

Yoshinobu Onuma; L Thuesen; Robert Jan van Geuns; M van der Ent; S Desch; J Fajadet; E Christiansen; P Smits; NR Holm; Evelyn Regar; Nicolas van Mieghem; V Borovicanin; D Paunovic; K Senshu; Gerrit-anne Es; Takashi Muramatsu; IS Lee; G Schuler; Felix Zijlstra; Hector Garcia Garcia; PWJC (Patrick) Serruys

doi:10.1093/eurheartj/ehs456

Randomized study to assess the effect of thrombus aspiration on flow area in patients with ST-elevation myocardial infarction: an optical frequency domain imaging study-TROFI trial

Yoshinobu Onuma
, L Thuesen
, Robert Jan van Geuns
, M van der Ent
, S Desch
, J Fajadet
, E Christiansen
, P Smits
, NR Holm
, Evelyn Regar
, Nicolas van Mieghem
, V Borovicanin
, D Paunovic
, K Senshu
, Gerrit-anne Es
, Takashi Muramatsu
, IS Lee
, G Schuler
, Felix Zijlstra
, Hector Garcia Garcia

PWJC (Patrick) Serruys

Research output: Contribution to journal › Article › Academic › peer-review

105 Citations (Scopus)

Abstract

Aims Primary percutaneous coronary intervention (PPCI) with thrombectomy (TB) seems to reduce the thrombus burden, resulting in a larger flow area as measured with optical frequency domain imaging (OFDI). Methods and results In a multi-centre study, 141 patients with ST elevation myocardial infarction,12 h from onset were randomized to either PPCI with TB using an Eliminate catheter (TB: n = 71) or without TB (non-TB: n = 70), having operators blinded for the OFDI results. The primary endpoint was minimum flow area (MinFA) post-procedure assessed by OFDI, defined as: [stent area + incomplete stent apposition (ISA) area] - (intraluminal defect + tissue prolapse area). Sample size was based on the Conclusion PPCI with TB was associated with a similar flow area as well as stent area to PPCI without TB.

Original language	Undefined/Unknown
Pages (from-to)	1050-1060b
Journal	European Heart Journal
Volume	34
Issue number	14
DOIs	https://doi.org/10.1093/eurheartj/ehs456
Publication status	Published - 2013

Research programs

EMC COEUR-09

Access to Document

10.1093/eurheartj/ehs456

http://hdl.handle.net/1765/63553

Cite this

Onuma, Y., Thuesen, L., van Geuns, R. J., van der Ent, M., Desch, S., Fajadet, J., Christiansen, E., Smits, P., Holm, NR., Regar, E., van Mieghem, N., Borovicanin, V., Paunovic, D., Senshu, K., Es, G., Muramatsu, T., Lee, IS., Schuler, G., Zijlstra, F., ... Serruys, PWJC. (2013). Randomized study to assess the effect of thrombus aspiration on flow area in patients with ST-elevation myocardial infarction: an optical frequency domain imaging study-TROFI trial. European Heart Journal, 34(14), 1050-1060b. https://doi.org/10.1093/eurheartj/ehs456

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title = "Randomized study to assess the effect of thrombus aspiration on flow area in patients with ST-elevation myocardial infarction: an optical frequency domain imaging study-TROFI trial",

abstract = "Aims Primary percutaneous coronary intervention (PPCI) with thrombectomy (TB) seems to reduce the thrombus burden, resulting in a larger flow area as measured with optical frequency domain imaging (OFDI). Methods and results In a multi-centre study, 141 patients with ST elevation myocardial infarction,12 h from onset were randomized to either PPCI with TB using an Eliminate catheter (TB: n = 71) or without TB (non-TB: n = 70), having operators blinded for the OFDI results. The primary endpoint was minimum flow area (MinFA) post-procedure assessed by OFDI, defined as: [stent area + incomplete stent apposition (ISA) area] - (intraluminal defect + tissue prolapse area). Sample size was based on the Conclusion PPCI with TB was associated with a similar flow area as well as stent area to PPCI without TB.",

author = "Yoshinobu Onuma and L Thuesen and \{van Geuns\}, \{Robert Jan\} and \{van der Ent\}, M and S Desch and J Fajadet and E Christiansen and P Smits and NR Holm and Evelyn Regar and \{van Mieghem\}, Nicolas and V Borovicanin and D Paunovic and K Senshu and Gerrit-anne Es and Takashi Muramatsu and IS Lee and G Schuler and Felix Zijlstra and \{Garcia Garcia\}, Hector and Serruys, \{PWJC (Patrick)\}",

year = "2013",

doi = "10.1093/eurheartj/ehs456",

language = "Undefined/Unknown",

volume = "34",

pages = "1050--1060b",

journal = "European Heart Journal",

issn = "0195-668X",

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Onuma, Y, Thuesen, L, van Geuns, RJ, van der Ent, M, Desch, S, Fajadet, J, Christiansen, E, Smits, P, Holm, NR, Regar, E, van Mieghem, N, Borovicanin, V, Paunovic, D, Senshu, K, Es, G, Muramatsu, T, Lee, IS, Schuler, G, Zijlstra, F, Garcia Garcia, H & Serruys, PWJC 2013, 'Randomized study to assess the effect of thrombus aspiration on flow area in patients with ST-elevation myocardial infarction: an optical frequency domain imaging study-TROFI trial', European Heart Journal, vol. 34, no. 14, pp. 1050-1060b. https://doi.org/10.1093/eurheartj/ehs456

Randomized study to assess the effect of thrombus aspiration on flow area in patients with ST-elevation myocardial infarction: an optical frequency domain imaging study-TROFI trial. / Onuma, Yoshinobu; Thuesen, L; van Geuns, Robert Jan et al.
In: European Heart Journal, Vol. 34, No. 14, 2013, p. 1050-1060b.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Randomized study to assess the effect of thrombus aspiration on flow area in patients with ST-elevation myocardial infarction: an optical frequency domain imaging study-TROFI trial

AU - Onuma, Yoshinobu

AU - Thuesen, L

AU - van Geuns, Robert Jan

AU - van der Ent, M

AU - Desch, S

AU - Fajadet, J

AU - Christiansen, E

AU - Smits, P

AU - Holm, NR

AU - Regar, Evelyn

AU - van Mieghem, Nicolas

AU - Borovicanin, V

AU - Paunovic, D

AU - Senshu, K

AU - Es, Gerrit-anne

AU - Muramatsu, Takashi

AU - Lee, IS

AU - Schuler, G

AU - Zijlstra, Felix

AU - Garcia Garcia, Hector

AU - Serruys, PWJC (Patrick)

PY - 2013

Y1 - 2013

N2 - Aims Primary percutaneous coronary intervention (PPCI) with thrombectomy (TB) seems to reduce the thrombus burden, resulting in a larger flow area as measured with optical frequency domain imaging (OFDI). Methods and results In a multi-centre study, 141 patients with ST elevation myocardial infarction,12 h from onset were randomized to either PPCI with TB using an Eliminate catheter (TB: n = 71) or without TB (non-TB: n = 70), having operators blinded for the OFDI results. The primary endpoint was minimum flow area (MinFA) post-procedure assessed by OFDI, defined as: [stent area + incomplete stent apposition (ISA) area] - (intraluminal defect + tissue prolapse area). Sample size was based on the Conclusion PPCI with TB was associated with a similar flow area as well as stent area to PPCI without TB.

AB - Aims Primary percutaneous coronary intervention (PPCI) with thrombectomy (TB) seems to reduce the thrombus burden, resulting in a larger flow area as measured with optical frequency domain imaging (OFDI). Methods and results In a multi-centre study, 141 patients with ST elevation myocardial infarction,12 h from onset were randomized to either PPCI with TB using an Eliminate catheter (TB: n = 71) or without TB (non-TB: n = 70), having operators blinded for the OFDI results. The primary endpoint was minimum flow area (MinFA) post-procedure assessed by OFDI, defined as: [stent area + incomplete stent apposition (ISA) area] - (intraluminal defect + tissue prolapse area). Sample size was based on the Conclusion PPCI with TB was associated with a similar flow area as well as stent area to PPCI without TB.

U2 - 10.1093/eurheartj/ehs456

DO - 10.1093/eurheartj/ehs456

M3 - Article

C2 - 23396493

SN - 0195-668X

VL - 34

SP - 1050-1060b

JO - European Heart Journal

JF - European Heart Journal

IS - 14

ER -