Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

R Sims, Sven van der Lee, AC Naj, C Bellenguez, N Badarinarayan, J Jakobsdottir, BW Kunkle, A Boland, R Raybould, JC Bis, ER Martin, B Grenier-Boley, S Heilmann-Heimbach, V Chouraki, AB Kuzma, K (Kristel) Sleegers, M Vronskaya, A Ruiz, RR Graham, R OlasoP Hoffmann, ML Grove, BN Vardarajan, M Hiltunen, MM Nothen, CC White, KL Hamilton-Nelson, J Epelbaum, W Maier, SH Choi, GW Beecham, C Dulary, S Herms, AV Smith, CC Funk, C Derbois, AJ Forstner, Shahzad Ahmad, HD Li, D Bacq, D Harold, CL Satizabal, O Valladares, A Squassina, R Thomas, JA Brody, LM Qu, P Sanchez-Juan, T Morgan, Frank Wolters, Y Zhao, FS Garcia, N Denning, M Fornage, J Malamon, MCD Naranjo, E Majounie, TH Mosley, B Dombroski, D Wallon, MK Lupton, J Dupuis, P Whitehead, L Fratiglioni, C Medway, XQ Jian, S Mukherjee, L Keller, K Brown, HH Lin, LB Cantwell, F Panza, B McGuinness, S Moreno-Grau, JD Burgess, V Solfrizzi, P Proitsi, Hieab Adams, M Allen, D Seripa, P Pastor, LA Cupples, ND Price, D Hannequin, A Frank-Garcia, D Levy, P Chakrabarty, P Caffarra, I Giegling, AS Beiser, V Giedraitis, H Hampel, ME Garcia, X Wang, L Lannfelt, P Mecocci, G Eiriksdottir, PK Crane, F Pasquier, V Boccardi, I Henandez, RC Barber, M Scherer, L Tarraga, PM Adams, M Leber, Y Chen, MS Albert, S Riedel-Heller, V Emilsson, D Beekly, A Braae, R Schmidt, D Blacker, C Masullo, H Schmidt, RS Doody, G Spalletta, WT Longstreth, TJ Fairchild, P Bossu, OL Lopez, MP Frosch, E Sacchinelli, B Ghetti, Q Yang, RM Huebinger, F Jessen, Shan Li, MI Kamboh, J Morris, O Sotolongo-Grau, MJ Katz, C Corcoran, M Dunstan, A Braddel, C Thomas, A Meggy, R Marshall, A Gerrish, J Chapman, M Aguilar, S Taylor, M Hill, MD Fairen, A Hodges, B Vellas, H Soininen, I Kloszewska, M Daniilidou, J Uphill, Y Patel, JT Hughes, J Lord, J Turton, AM Hartmann, R Cecchetti, C Fenoglio, M Serpente, M Arcaro, C Caltagirone, MD Orfei, A Ciaramella, S Pichler, M Mayhaus, W Gu, A Lleo, J Forte, R Blesa, IS Barber, K Brookes, C Cupidi, RG Maletta, D Carrell, S Sorbi, S Moebus, M Urbano, A Pilotto, J Kornhuber, P Bosco, S Todd, D Craig, J Johnston, M Gill, B Lawlor, A Lynch, NC Fox, J Hardy, RL Albin, LG Apostolova, SE Arnold, S Asthana, CS Atwood, CT Baldwin, LL Barnes, S Barral, TG Beach, JT Becker, EH Bigio, TD Bird, BF Boeve, JD Bowen, A Boxer, JR Burke, JM Burns, JD Buxbaum, NJ Cairns, CH Cao, CS Carlson, CM Carlsson, RM Carney, MM Carrasquillo, SL Carroll, CC Diaz, HC Chui, DG Clark, DH Cribbs, EA Crocco, C DeCarli, M Dick, R Duara, DA Evans, KM Faber, KB Fallon, DW Fardo, MR Farlow, S Ferris, TM Foroud, DR Galasko, M Gearing, DH Geschwind, JR Gilbert, NR Graff-Radford, RC Green, JH Growdon, RL Hamilton, LE Harrell, LS Honig, MJ Huentelman, CM Hulette, BT Hyman, GP Jarvik, E Abner, LW Jin, G Jun, A Karydas, JA Kaye, R Kim, NW Kowall, JH Kramer, FM LaFerla, JJ Lah, JB Leverenz, AI Levey, G Li, AP Lieberman, KL Lunetta, CG Lyketsos, DC Marson, F Martiniuk, DC Mash, E Masliah, WC McCormick, SM McCurry, AN McDavid, AC McKee, M Mesulam, BL Miller, CA Miller, JW Miller, JC Morris, JR Murrell, AJ Myers, S O'Bryant, VS Pankratz, V Pankratz, JE Parisi, HL Paulson, W Perry, E Peskind, A Pierce, WW Poon, H Potter, JF Quinn, A Raj, M Raskind, B Reisberg, C Reitz, JM Ringman, ED Roberson, E Rogaeva, HJ Rosen, RN Rosenberg, MA Sager, AJ Saykin, JA Schneider, LS Schneider, WW Seeley, AG Smith, JA Sonnen, S Spina, RA Stern, RH Swerdlow, RE Tanzi, TA Thornton-Wells, JQ Trojanowski, JC Troncoso, VM Van Deerlin, LJ Van Eldik, HV Vinters, JP Vonsattel, S Weintraub, KA Welsh-Bohmer, KC Wilhelmsen, J Williamson, RL Woltjer, CB Wright, CE Yu, L Yu, F Garzia, F Golamaully, G Septier, S Engelborghs, R Vandenberghe, PP de Deyn, CM Fernadez, YA Benito, H Thonberg, C Forsell, L Lilius, A Kinhult-Stahlbom, L Kilander, R Brundin, L Concari, S Helisalmi, AM Koivisto, A Haapasalo, V Dermecourt, N Fievet, O Hanon, C Dufouil, A Brice, K Ritchie, B Dubois, JJ Himali, CD Keene, J Tschanz, AL Fitzpatrick, WA Kukull, M Norton, T Aspelund, EB Larson, R Munger, JI Rotter, RB Lipton, MJ Bullido, Bert Hofman, TJ Montine, E Coto, E Boerwinkle, RC Petersen, V Alvarez, Fernando Rivadeneira, EM Reiman, M Gallo, CJ O'Donnell, JS Reisch, AC Bruni, DR Royall, M Dichgans, M Sano, D Galimberti, P St George-Hyslop, E Scarpini, DW Tsuang, M Mancuso, U Bonuccelli, AR Winslow, A Daniele, CK Wu, O Peters, B Nacmias, M Riemenschneider, R Heun, C Brayne, DC Rubinsztein, J Bras, R Guerreiro, A Al-Chalabi, CE Shaw, J Collinge, D Mann, M Tsolaki, J Clarimon, R Sussams, S Lovestone, MC O'Donovan, MJ Owen, TW Behrens, S Mead, AM Goate, André Uitterlinden, C Holmes, C Cruchaga, M Ingelsson, DA Bennett, J Powell, TE Golde, C Graff, PL De Jager, K Morgan, N Ertekin-Taner, O Combarros, BM Psaty, P Passmore, SG Younkin, C Berr, V Gudnason, D Rujescu, DW Dickson, JF Dartigues, AL DeStefano, S Ortega-Cubero, H Hakonarson, D Campion, M Boada, JK Kauwe, LA Farrer, C van Broeckhoven, Arfan Ikram, L Jones, JL Haines, C Tzourio, LJ Launer, V Escott-Price, R Mayeux, JF Deleuze, Najaf Amin, PA Holmans, MA Pericak-Vance, P Amouyel, Cornelia Duijn, A Ramirez, LS (Li-San) Wang, JC Lambert, S Seshadri, J Williams, GD Schellenberg

Research output: Contribution to journal › Article › Academic › peer-review

685 Citations (Scopus)
Original languageUndefined/Unknown
Pages (from-to)1373-+
JournalNature Genetics
Volume49
Issue number9
DOIs
Publication statusPublished - 2017

Research programs

  • EMC NIHES-01-64-03

Access to Document

Cite this