Reaching out for the other end with p53-binding protein 1

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Abstract

Correct joining of broken chromosomes is indispensable to prevent cell death, ageing and cancer. Two recent papers highlight the importance of p53-binding protein 1 (53BP1) in connecting distant sites in T-cell receptor loci and dysfunctional telomeres. These studies refine our understanding of the specific subset of DNA double-strand breaks that require the accessory end-joining factor 53BP1.
Original languageUndefined/Unknown
Pages (from-to)226-229
Number of pages4
JournalTrends in Biochemical Sciences
Volume34
Issue number5
DOIs
Publication statusPublished - 2009

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