Reaching out for the other end with p53-binding protein 1

Dik van Gent

doi:10.1016/j.tibs.2009.01.009

Reaching out for the other end with p53-binding protein 1

Dik van Gent

Molecular Genetics

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Abstract

Correct joining of broken chromosomes is indispensable to prevent cell death, ageing and cancer. Two recent papers highlight the importance of p53-binding protein 1 (53BP1) in connecting distant sites in T-cell receptor loci and dysfunctional telomeres. These studies refine our understanding of the specific subset of DNA double-strand breaks that require the accessory end-joining factor 53BP1.

Original language	Undefined/Unknown
Pages (from-to)	226-229
Number of pages	4
Journal	Trends in Biochemical Sciences
Volume	34
Issue number	5
DOIs	https://doi.org/10.1016/j.tibs.2009.01.009
Publication status	Published - 2009

Research programs

EMC MGC-01-12-03

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.tibs.2009.01.009

http://hdl.handle.net/1765/27037

Cite this

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title = "Reaching out for the other end with p53-binding protein 1",

abstract = "Correct joining of broken chromosomes is indispensable to prevent cell death, ageing and cancer. Two recent papers highlight the importance of p53-binding protein 1 (53BP1) in connecting distant sites in T-cell receptor loci and dysfunctional telomeres. These studies refine our understanding of the specific subset of DNA double-strand breaks that require the accessory end-joining factor 53BP1.",

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AB - Correct joining of broken chromosomes is indispensable to prevent cell death, ageing and cancer. Two recent papers highlight the importance of p53-binding protein 1 (53BP1) in connecting distant sites in T-cell receptor loci and dysfunctional telomeres. These studies refine our understanding of the specific subset of DNA double-strand breaks that require the accessory end-joining factor 53BP1.

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