Recent advances in the genetics of dementia with Lewy bodies

Vincenzo Bonifati

doi:10.1007/s11910-008-0030-1

Recent advances in the genetics of dementia with Lewy bodies

Vincenzo Bonifati

Clinical Genetics

Research output: Contribution to journal › Article › Academic

18 Citations (Scopus)

Abstract

In the past few years, mutations have been identified in the genes encoding alpha-synuclein, leucine-rich repeat kinase 2, and glucocerebrosidase in some patients with dementia with Lewy bodies (DLB). Furthermore, a novel locus for familial DLB has been mapped to chromosome 2q35-q36. Collectively, these discoveries highlight a substantial overlap between the known genetic determinants of Parkinson's disease and DLB, as well as the presence of profound etiologic heterogeneity in Lewy body disorders.

Original language	Undefined/Unknown
Pages (from-to)	187-189
Number of pages	3
Journal	Current Neurology and Neuroscience Reports
Volume	8
Issue number	3
DOIs	https://doi.org/10.1007/s11910-008-0030-1
Publication status	Published - 2008

Research programs

EMC MGC-02-96-01

Access to Document

10.1007/s11910-008-0030-1

http://hdl.handle.net/1765/32332

Cite this

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title = "Recent advances in the genetics of dementia with Lewy bodies",

abstract = "In the past few years, mutations have been identified in the genes encoding alpha-synuclein, leucine-rich repeat kinase 2, and glucocerebrosidase in some patients with dementia with Lewy bodies (DLB). Furthermore, a novel locus for familial DLB has been mapped to chromosome 2q35-q36. Collectively, these discoveries highlight a substantial overlap between the known genetic determinants of Parkinson's disease and DLB, as well as the presence of profound etiologic heterogeneity in Lewy body disorders.",

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AB - In the past few years, mutations have been identified in the genes encoding alpha-synuclein, leucine-rich repeat kinase 2, and glucocerebrosidase in some patients with dementia with Lewy bodies (DLB). Furthermore, a novel locus for familial DLB has been mapped to chromosome 2q35-q36. Collectively, these discoveries highlight a substantial overlap between the known genetic determinants of Parkinson's disease and DLB, as well as the presence of profound etiologic heterogeneity in Lewy body disorders.

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