Recent Clinical Developments of Nanomediated Drug Delivery Systems of Taxanes for the Treatment of Cancer

Ruben van Eerden*, Ron Mathijssen, Stijn Koolen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)
8 Downloads (Pure)

Abstract

Conventional taxanes are used as cornerstone of the chemotherapeutical treatment for a variety of malignancies. Nevertheless, a large proportion of patients do not benefit from their treatment while they do suffer from severe adverse events related to the solvent or to the active compound. Cremophor EL and polysorbate 80 free formulations, conjugates, oral formulations and different types of drug delivery systems are some examples of the several attempts to improve the treatment with taxanes. In this review article, we discuss recent clinical developments of nanomediated drug delivery systems of taxanes for the treatment of cancer. Targeting mechanisms of drug delivery systems and characteristics of the most commonly used taxane-containing drug delivery systems in the clinical setting will be discussed in this review.

Original languageEnglish
Pages (from-to)8151-8166
Number of pages16
JournalInternational Journal of Nanomedicine
Volume15
DOIs
Publication statusPublished - 22 Oct 2020

Bibliographical note

Publisher Copyright:
© 2020 van Eerden et al.

Research programs

  • EMC OR-01

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