Recidiverende infecties met Clostridium dificile

Translated title of the contribution: Relapsing infections with Clostridium difficile

W E Visser, A M Dingemans-Dumas, D J Bac

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Two women, aged 78 and 85 years, presented with watery diarrhoea and fever after a course of antibiotic therapy. Pseudo-membranous colitis was diagnosed, which was adequately treated. In both patients the C. difficile colitis relapsed, which was successfully treated with a pulse and tapering scheme of vancomycin. C. difficile infection is a frequent cause of antibiotic-associated diarrhoea. Clinical presentation can vary in severity. Cytotoxin testing, immunoassay and endoscopy are important tools in diagnosing C. difficile colitis. Like the first infection, the first relapse must be treated with metronidazole or vancomycin. To treat a second relapse, a pulse and tapering dose of vancomycin has been recommended. Nevertheless, multiple recurrences may occur, which are difficult to treat.

Translated title of the contributionRelapsing infections with Clostridium difficile
Original languageDutch
Pages (from-to)2381-5
Number of pages5
JournalNederlands Tijdschrift voor Geneeskunde
Volume149
Issue number43
Publication statusPublished - 22 Oct 2005
Externally publishedYes

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