TY - JOUR
T1 - Recombinant factor VIIa in orthotopic liver transplantation
T2 - Influence on parameters of coagulation and fibrinolysis
AU - Meijer, Karina
AU - Hendriks, Herman G.D.
AU - De Wolf, Joost Th M.
AU - Klompmaker, Ids J.
AU - Lisman, Ton
AU - Hagenaars, Ans A.M.
AU - Slooff, Maarten J.H.
AU - Porte, Robert J.
AU - van der Meer, Jan
PY - 2003/2
Y1 - 2003/2
N2 - The effect of recombinant factor VIIa (rFVIIa) on blood loss was evaluated in cirrhotic patients undergoing orthotopic liver transplantation. In the present study, we explored the effect of rFVIIa on coagulation and fibrinolysis during orthotopic liver transplantation. Coagulation factors, parameters of thrombin generation and parameters of fibrinolysis were measured in six patients who had received a single dose of 80 μg/kg rFVIIa and in ten controls, during and after orthotopic liver transplantation. Baseline concentrations and course of coagulation factors were similar in patients and controls. Thrombin generation did not rise after the administration of rFVIIa, but showed a sharp increase after reperfusion in patients, as compared with controls. No difference in fibrinolysis was apparent between patients and controls. No evidence of diffuse intravascular coagulation was seen. We conclude that the use of rFVIIa in orthotopic liver transplantation seems to enhance thrombin generation in a localized and time-limited matter, without causing systemic coagulation.
AB - The effect of recombinant factor VIIa (rFVIIa) on blood loss was evaluated in cirrhotic patients undergoing orthotopic liver transplantation. In the present study, we explored the effect of rFVIIa on coagulation and fibrinolysis during orthotopic liver transplantation. Coagulation factors, parameters of thrombin generation and parameters of fibrinolysis were measured in six patients who had received a single dose of 80 μg/kg rFVIIa and in ten controls, during and after orthotopic liver transplantation. Baseline concentrations and course of coagulation factors were similar in patients and controls. Thrombin generation did not rise after the administration of rFVIIa, but showed a sharp increase after reperfusion in patients, as compared with controls. No difference in fibrinolysis was apparent between patients and controls. No evidence of diffuse intravascular coagulation was seen. We conclude that the use of rFVIIa in orthotopic liver transplantation seems to enhance thrombin generation in a localized and time-limited matter, without causing systemic coagulation.
UR - http://www.scopus.com/inward/record.url?scp=0037297270&partnerID=8YFLogxK
U2 - 10.1097/00001721-200302000-00008
DO - 10.1097/00001721-200302000-00008
M3 - Article
C2 - 12632027
AN - SCOPUS:0037297270
SN - 0957-5235
VL - 14
SP - 169
EP - 174
JO - Blood Coagulation and Fibrinolysis
JF - Blood Coagulation and Fibrinolysis
IS - 2
ER -