Recombinant porcine surfactant protein D inhibits influenza A virus replication ex vivo

Marine Hillaire, M (Marco) van Eijk, Stella Trierum, Ron Fouchier, Ab Osterhaus, HP Haagsman, Guus Rimmelzwaan

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Abstract

Influenza is a major burden to public health. Due to high mutation rates and selection pressure, mutant viruses emerge which are resistant to currently used antiviral drugs. Therefore, there is a need for the development of novel classes of antiviral drugs that suffer less from the emergence of resistant viruses. Antiviral drugs based on collectin-like surfactant protein D (SP-D) may fulfil these requirements. Especially porcine SP-D displays strong antiviral activity to influenza A viruses. In the present study the antiviral activity of recombinant porcine SP-D was investigated in ex vivo cultures of respiratory tract tissue infected with human influenza A virus of the H3N2 subtype. Porcine SP-D has antiviral activity in these test systems. It is suggested that porcine SP-D may be used as a venue to develop a novel class of antiviral drugs. (C) 2014 Elsevier B.V. All rights reserved.
Original languageUndefined/Unknown
Pages (from-to)22-26
Number of pages5
JournalVirus Research
Volume181
DOIs
Publication statusPublished - 2014

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