Recommendations for pregnancies in patients with Crigler-Najjar syndrome

J. H.Paul Wilson, Maarten Sinaasappel, Fred K. Lotgering, Janneke G. Langendonk*

*Corresponding author for this work

Research output: Chapter/Conference proceedingChapterAcademic

4 Citations (Scopus)


During pregnancy, the developing foetus in mothers with Crigler-Najjar type 1 and 2 is exposed to raised levels of unconjugated bilirubin, with the risk of neurotoxicity. We describe two pregnancies in a patient with Crigler-Najjar type 2, who was carefully monitored prior to and during pregnancy and phototherapy adjusted to maintain serum bilirubin levels below 200 μmol/l and the bilirubin/albumin molar ratio below 50%. Both pregnancies resulted in normal delivery of healthy infants who had normal neurological development. A review of all reported pregnancies in Crigler-Najjar patients and a set of recommendations are presented.

Original languageEnglish
Title of host publicationJIMD Reports
Number of pages4
Publication statusPublished - 2013

Publication series

SeriesJIMD Reports

Bibliographical note

Publisher Copyright:
© SSIEM and Springer-Verlag Berlin Heidelberg 2012.


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