TY - JOUR
T1 - Recruitment and baseline characteristics of young adults at risk of early-onset knee osteoarthritis after ACL reconstruction in the SUPER-Knee trial
AU - Culvenor, Adam G.
AU - West, Thomas J.
AU - Bruder, Andrea M.
AU - On behalf of the SUPER-Knee Study Group
AU - Scholes, Mark J.
AU - Barton, Christian J.
AU - Roos, Ewa M.
AU - Oei, Edwin H.G.
AU - McPhail, Steven M.
AU - Souza, Richard B.
AU - Lee, Jusuk
AU - Patterson, Brooke E.
AU - Girdwood, Michael A.
AU - Couch, Jamon L.
AU - Crossley, Kay M.
AU - Kimmel, Lara
AU - Liew, Susan
AU - Cross, Emily
AU - Cimoli, Chris
AU - Hardidge, Andrew
AU - Choong, Peter
AU - Roddy, Leanne
AU - Spiers, Libby
AU - Tran, Phong
AU - Schoch, Peter
AU - Bailey, Katelyn
AU - Page, Richard
AU - Lewis, Leonie
AU - Morris, Hayden
AU - White, Nathan
AU - Evans, Matthew
AU - Carr, Ashley
AU - Wong, Justin
AU - Van Bavel, Dirk
AU - Alexander, Matthew
AU - Talbot, Simon
AU - Kjar, Richard
AU - Spencer, Luke
AU - Hau, Raphael
AU - Haberfield, Melissa
AU - To, Laura
AU - Evans, Sebastian
N1 - Publisher Copyright:
© Author(s) (or their employer(s)) 2024.
PY - 2024/4/4
Y1 - 2024/4/4
N2 - Objectives:The study aims to (1) report the process of recruiting young adults into a secondary knee osteoarthritis prevention randomised controlled trial (RCT) after anterior cruciate ligament reconstruction (ACLR); (2) determine the number of individuals needed to be screened to include one participant (NNS) and (3) report baseline characteristics of randomised participants. Methods:The SUpervised exercise-therapy and Patient Education Rehabilitation (SUPER)-Knee RCT compares SUPER and minimal intervention for young adults (aged 18-40 years) with ongoing symptoms (ie, mean score of <80/100 from four Knee injury and Osteoarthritis Outcome Score subscales (KOOS4)) 9-36 months post-ACLR. The NNS was calculated as the number of prospective participants screened to enrol one person. At baseline, participants provided medical history, completed questionnaires (demographic, injury/surgery, rehabilitation characteristics) and underwent physical examination. Results:1044 individuals were screened to identify 567 eligible people, from which 184 participants (63% male) enrolled. The sample of enrolled participants was multicultural (29% born outside Australia; 2% Indigenous Australians). The NNS was 5.7. For randomised participants, mean±SD age was 30±6 years. The mean body mass index was 27.3±5.2 kg/m2, with overweight (43%) and obesity (21%) common. Participants were, on average, 2.3 years post-ACLR. Over half completed <8 months of postoperative rehabilitation, with 56% having concurrent injury/surgery to meniscus and/or cartilage. The most affected KOOS (0=worst, 100=best) subscale was quality of life (mean 43.7±19.1). Conclusion:Young adults post-ACLR were willing to participate in a secondary osteoarthritis prevention trial. Sample size calculations should be multiplied by at least 5.7 to provide an estimate of the NNS. The SUPER-Knee cohort is ideally positioned to monitor and intervene in the early development and trajectory of osteoarthritis.
AB - Objectives:The study aims to (1) report the process of recruiting young adults into a secondary knee osteoarthritis prevention randomised controlled trial (RCT) after anterior cruciate ligament reconstruction (ACLR); (2) determine the number of individuals needed to be screened to include one participant (NNS) and (3) report baseline characteristics of randomised participants. Methods:The SUpervised exercise-therapy and Patient Education Rehabilitation (SUPER)-Knee RCT compares SUPER and minimal intervention for young adults (aged 18-40 years) with ongoing symptoms (ie, mean score of <80/100 from four Knee injury and Osteoarthritis Outcome Score subscales (KOOS4)) 9-36 months post-ACLR. The NNS was calculated as the number of prospective participants screened to enrol one person. At baseline, participants provided medical history, completed questionnaires (demographic, injury/surgery, rehabilitation characteristics) and underwent physical examination. Results:1044 individuals were screened to identify 567 eligible people, from which 184 participants (63% male) enrolled. The sample of enrolled participants was multicultural (29% born outside Australia; 2% Indigenous Australians). The NNS was 5.7. For randomised participants, mean±SD age was 30±6 years. The mean body mass index was 27.3±5.2 kg/m2, with overweight (43%) and obesity (21%) common. Participants were, on average, 2.3 years post-ACLR. Over half completed <8 months of postoperative rehabilitation, with 56% having concurrent injury/surgery to meniscus and/or cartilage. The most affected KOOS (0=worst, 100=best) subscale was quality of life (mean 43.7±19.1). Conclusion:Young adults post-ACLR were willing to participate in a secondary osteoarthritis prevention trial. Sample size calculations should be multiplied by at least 5.7 to provide an estimate of the NNS. The SUPER-Knee cohort is ideally positioned to monitor and intervene in the early development and trajectory of osteoarthritis.
UR - http://www.scopus.com/inward/record.url?scp=85189675220&partnerID=8YFLogxK
U2 - 10.1136/bmjsem-2024-001909
DO - 10.1136/bmjsem-2024-001909
M3 - Article
C2 - 38601122
AN - SCOPUS:85189675220
SN - 2055-7647
VL - 10
JO - BMJ Open Sport and Exercise Medicine
JF - BMJ Open Sport and Exercise Medicine
IS - 2
M1 - e001909
ER -
