Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naïve/memory Breg ratio during a relapse but not in remission

Stephanie Knippenberg; Evelyn Peelen; Joost Smolders; Mariëlle Thewissen; Paul Menheere; Jan Willem Cohen Tervaert; Raymond Hupperts; Jan Damoiseaux

doi:10.1016/j.jneuroim.2011.08.019

Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naïve/memory Breg ratio during a relapse but not in remission

Stephanie Knippenberg^*, Evelyn Peelen, Joost Smolders, Mariëlle Thewissen, Paul Menheere, Jan Willem Cohen Tervaert, Raymond Hupperts, Jan Damoiseaux

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

160 Citations (Scopus)

Abstract

In this study, we assessed B cell subsets, including Bregs, during stable and active disease in relapsing remitting multiple sclerosis (RRMS) patients and related B cell subsets to vitamin D status. We report that RRMS patients have a decreased percentage of both memory B cells and Bregs compared to healthy controls. During a relapse, the reduction in Bregs involved in particular naïve Bregs. We found no correlation between vitamin D status and B cell subsets. An effect of vitamin D on Bregs cannot be ruled out, since it might be the function that is interfered with instead of relative numbers.

Original language	English
Pages (from-to)	80-86
Number of pages	7
Journal	Journal of Neuroimmunology
Volume	239
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2011.08.019
Publication status	Published - 28 Oct 2011
Externally published	Yes

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10.1016/j.jneuroim.2011.08.019

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Knippenberg, S., Peelen, E., Smolders, J., Thewissen, M., Menheere, P., Cohen Tervaert, J. W., Hupperts, R., & Damoiseaux, J. (2011). Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naïve/memory Breg ratio during a relapse but not in remission. Journal of Neuroimmunology, 239(1-2), 80-86. https://doi.org/10.1016/j.jneuroim.2011.08.019

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title = "Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced na{\"i}ve/memory Breg ratio during a relapse but not in remission",

abstract = "In this study, we assessed B cell subsets, including Bregs, during stable and active disease in relapsing remitting multiple sclerosis (RRMS) patients and related B cell subsets to vitamin D status. We report that RRMS patients have a decreased percentage of both memory B cells and Bregs compared to healthy controls. During a relapse, the reduction in Bregs involved in particular na{\"i}ve Bregs. We found no correlation between vitamin D status and B cell subsets. An effect of vitamin D on Bregs cannot be ruled out, since it might be the function that is interfered with instead of relative numbers.",

author = "Stephanie Knippenberg and Evelyn Peelen and Joost Smolders and Mari{\"e}lle Thewissen and Paul Menheere and {Cohen Tervaert}, {Jan Willem} and Raymond Hupperts and Jan Damoiseaux",

year = "2011",

month = oct,

day = "28",

doi = "10.1016/j.jneuroim.2011.08.019",

language = "English",

volume = "239",

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Knippenberg, S, Peelen, E, Smolders, J, Thewissen, M, Menheere, P, Cohen Tervaert, JW, Hupperts, R & Damoiseaux, J 2011, 'Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naïve/memory Breg ratio during a relapse but not in remission', Journal of Neuroimmunology, vol. 239, no. 1-2, pp. 80-86. https://doi.org/10.1016/j.jneuroim.2011.08.019

Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naïve/memory Breg ratio during a relapse but not in remission. / Knippenberg, Stephanie; Peelen, Evelyn; Smolders, Joost et al.
In: Journal of Neuroimmunology, Vol. 239, No. 1-2, 28.10.2011, p. 80-86.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naïve/memory Breg ratio during a relapse but not in remission

AU - Knippenberg, Stephanie

AU - Peelen, Evelyn

AU - Smolders, Joost

AU - Thewissen, Mariëlle

AU - Menheere, Paul

AU - Cohen Tervaert, Jan Willem

AU - Hupperts, Raymond

AU - Damoiseaux, Jan

PY - 2011/10/28

Y1 - 2011/10/28

N2 - In this study, we assessed B cell subsets, including Bregs, during stable and active disease in relapsing remitting multiple sclerosis (RRMS) patients and related B cell subsets to vitamin D status. We report that RRMS patients have a decreased percentage of both memory B cells and Bregs compared to healthy controls. During a relapse, the reduction in Bregs involved in particular naïve Bregs. We found no correlation between vitamin D status and B cell subsets. An effect of vitamin D on Bregs cannot be ruled out, since it might be the function that is interfered with instead of relative numbers.

AB - In this study, we assessed B cell subsets, including Bregs, during stable and active disease in relapsing remitting multiple sclerosis (RRMS) patients and related B cell subsets to vitamin D status. We report that RRMS patients have a decreased percentage of both memory B cells and Bregs compared to healthy controls. During a relapse, the reduction in Bregs involved in particular naïve Bregs. We found no correlation between vitamin D status and B cell subsets. An effect of vitamin D on Bregs cannot be ruled out, since it might be the function that is interfered with instead of relative numbers.

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SN - 0165-5728

VL - 239

SP - 80

EP - 86

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naïve/memory Breg ratio during a relapse but not in remission

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