TY - JOUR
T1 - Reduction in thrombotic events with heparin-coated Palmaz-Schatz stents in normal porcine coronary arteries
AU - Hårdhammar, Peter A.
AU - van Beusekom, Heleen M.M.
AU - Emanuelsson, Håkan U.
AU - Hofma, Sjoerd H.
AU - Albertsson, Per A.
AU - Verdouw, Pietr D.
AU - Boersma, Eric
AU - Serruys, Patrick W.
AU - Van der Giessen, Willem J.
N1 - Copyright © 1996 by American Heart Association
PY - 1996/2
Y1 - 1996/2
N2 - Background: The use of stents improves the result after balloon coronary angioplasty. Thrombogenicity of stents is, however, a concern. In the present study, we compared stents with an antithrombotic coating with regular stents. Methods and Results: Regular stents were placed in coronary arteries of pigs receiving no aspirin (group 1; n=8) or aspirin over 4 weeks (group 2, n = 10) or 12 weeks (group 3, n = 9). Stents coated with heparin (antithrombin III uptake, 5 pmol/stent) were placed in 7 pigs that did not receive aspirin (group 4). The other animals received aspirin and coated stents with a heparin activity of 12 pmol antithrombin III/stent (group 5, n = 10) or 20 pmol/stent (group 6, n = 10; group 7, n = 10). Quantitative arteriography was performed at implantation and after 4 (groups 1, 2, and 4 through 6) or 12 weeks (groups 3 and 7). In an additional 5 animals, five regular and five coated stents (20 pmol/stent) were placed and explanted after 5 days for examination of the early responses to the implants. Thrombotic occlusion of the regular stent occurred in 9 of 27 in groups 1 through 3. However, in 0 of 30 of the animals receiving high-activity heparin-coated stents (groups 5 through 7), thrombotic stent occlusion was observed (P<.001). Histological analysis at 4 weeks showed that the neointima in group 6 was thicker compared with its control group 2 (259 ± 104 and 117 ± 36 μm, P<.01), but at 12 weeks the thickness was similar (152 ± 61 and 198 ± 49 μm, respectively). Comparison at 5 days suggested delayed endothelialization of the coating. Conclusions: High-activity heparin coating of stents eliminates subacute thrombosis in porcine coronary arteries.
AB - Background: The use of stents improves the result after balloon coronary angioplasty. Thrombogenicity of stents is, however, a concern. In the present study, we compared stents with an antithrombotic coating with regular stents. Methods and Results: Regular stents were placed in coronary arteries of pigs receiving no aspirin (group 1; n=8) or aspirin over 4 weeks (group 2, n = 10) or 12 weeks (group 3, n = 9). Stents coated with heparin (antithrombin III uptake, 5 pmol/stent) were placed in 7 pigs that did not receive aspirin (group 4). The other animals received aspirin and coated stents with a heparin activity of 12 pmol antithrombin III/stent (group 5, n = 10) or 20 pmol/stent (group 6, n = 10; group 7, n = 10). Quantitative arteriography was performed at implantation and after 4 (groups 1, 2, and 4 through 6) or 12 weeks (groups 3 and 7). In an additional 5 animals, five regular and five coated stents (20 pmol/stent) were placed and explanted after 5 days for examination of the early responses to the implants. Thrombotic occlusion of the regular stent occurred in 9 of 27 in groups 1 through 3. However, in 0 of 30 of the animals receiving high-activity heparin-coated stents (groups 5 through 7), thrombotic stent occlusion was observed (P<.001). Histological analysis at 4 weeks showed that the neointima in group 6 was thicker compared with its control group 2 (259 ± 104 and 117 ± 36 μm, P<.01), but at 12 weeks the thickness was similar (152 ± 61 and 198 ± 49 μm, respectively). Comparison at 5 days suggested delayed endothelialization of the coating. Conclusions: High-activity heparin coating of stents eliminates subacute thrombosis in porcine coronary arteries.
UR - http://www.scopus.com/inward/record.url?scp=0030067483&partnerID=8YFLogxK
U2 - 10.1161/01.CIR.93.3.423
DO - 10.1161/01.CIR.93.3.423
M3 - Article
C2 - 8565158
AN - SCOPUS:0030067483
SN - 0009-7322
VL - 93
SP - 423
EP - 430
JO - Circulation
JF - Circulation
IS - 3
ER -