Reduction of immunosuppressive tumor microenvironment in cholangiocarcinoma by ex vivo targeting immune checkpoint molecules

Guoying Zhou; Dave Sprengers; Shanta Mancham; Remco Erkens; Patrick Boor; Adriaan Beek; Michail Doukas; Lisanne Noordam; Lucia Campos Carrascosa; Valeska Ruiter; Roelof van Leeuwen; Wojtek Polak; Jeroen de Jonge; B Groot Koerkamp; B van Rosmalen; TM Gulik; J Verheij; J.N.M. IJzermans; Marco Bruno; Jaap Kwekkeboom

doi:10.1016/j.jhep.2019.05.026

Reduction of immunosuppressive tumor microenvironment in cholangiocarcinoma by ex vivo targeting immune checkpoint molecules

Guoying Zhou, Dave Sprengers, Shanta Mancham, Remco Erkens, Patrick Boor, Adriaan Beek, Michail Doukas, Lisanne Noordam, Lucia Campos Carrascosa, Valeska Ruiter, Roelof van Leeuwen, Wojtek Polak, Jeroen de Jonge, B Groot Koerkamp, B van Rosmalen, TM Gulik, J Verheij, J.N.M. IJzermans, Marco Bruno, Jaap Kwekkeboom

Research output: Contribution to journal › Article › Academic › peer-review

99 Citations (Scopus)

Original language	Undefined/Unknown
Pages (from-to)	753-762
Number of pages	10
Journal	Journal of Hepatology
Volume	71
Issue number	4
DOIs	https://doi.org/10.1016/j.jhep.2019.05.026
Publication status	Published - 2019

Research programs

EMC MM-03-24-01
EMC MM-03-86-08
EMC MM-04-47-07

Access to Document

10.1016/j.jhep.2019.05.026

http://hdl.handle.net/1765/119956

Cite this

Zhou, G., Sprengers, D., Mancham, S., Erkens, R., Boor, P., Beek, A., Doukas, M., Noordam, L., Campos Carrascosa, L., Ruiter, V., van Leeuwen, R., Polak, W., de Jonge, J., Groot Koerkamp, B., van Rosmalen, B., Gulik, TM., Verheij, J., IJzermans, J. N. M., Bruno, M., & Kwekkeboom, J. (2019). Reduction of immunosuppressive tumor microenvironment in cholangiocarcinoma by ex vivo targeting immune checkpoint molecules. Journal of Hepatology, 71(4), 753-762. https://doi.org/10.1016/j.jhep.2019.05.026

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title = "Reduction of immunosuppressive tumor microenvironment in cholangiocarcinoma by ex vivo targeting immune checkpoint molecules",

author = "Guoying Zhou and Dave Sprengers and Shanta Mancham and Remco Erkens and Patrick Boor and Adriaan Beek and Michail Doukas and Lisanne Noordam and {Campos Carrascosa}, Lucia and Valeska Ruiter and {van Leeuwen}, Roelof and Wojtek Polak and {de Jonge}, Jeroen and {Groot Koerkamp}, B and {van Rosmalen}, B and TM Gulik and J Verheij and J.N.M. IJzermans and Marco Bruno and Jaap Kwekkeboom",

year = "2019",

doi = "10.1016/j.jhep.2019.05.026",

language = "Undefined/Unknown",

volume = "71",

pages = "753--762",

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Zhou, G, Sprengers, D , Mancham, S, Erkens, R, Boor, P, Beek, A , Doukas, M , Noordam, L, Campos Carrascosa, L, Ruiter, V, van Leeuwen, R , Polak, W , de Jonge, J , Groot Koerkamp, B, van Rosmalen, B, Gulik, TM, Verheij, J, IJzermans, JNM , Bruno, M & Kwekkeboom, J 2019, 'Reduction of immunosuppressive tumor microenvironment in cholangiocarcinoma by ex vivo targeting immune checkpoint molecules', Journal of Hepatology, vol. 71, no. 4, pp. 753-762. https://doi.org/10.1016/j.jhep.2019.05.026

TY - JOUR

T1 - Reduction of immunosuppressive tumor microenvironment in cholangiocarcinoma by ex vivo targeting immune checkpoint molecules

AU - Zhou, Guoying

AU - Sprengers, Dave

AU - Mancham, Shanta

AU - Erkens, Remco

AU - Boor, Patrick

AU - Beek, Adriaan

AU - Doukas, Michail

AU - Noordam, Lisanne

AU - Campos Carrascosa, Lucia

AU - Ruiter, Valeska

AU - van Leeuwen, Roelof

AU - Polak, Wojtek

AU - de Jonge, Jeroen

AU - Groot Koerkamp, B

AU - van Rosmalen, B

AU - Gulik, TM

AU - Verheij, J

AU - IJzermans, J.N.M.

AU - Bruno, Marco

AU - Kwekkeboom, Jaap

PY - 2019

Y1 - 2019

U2 - 10.1016/j.jhep.2019.05.026

DO - 10.1016/j.jhep.2019.05.026

M3 - Article

C2 - 31195061

SN - 0168-8278

VL - 71

SP - 753

EP - 762

JO - Journal of Hepatology

JF - Journal of Hepatology

IS - 4

ER -