Reference ranges of anti‐Müllerian hormone and interaction with placental biomarkers in early pregnancy: the Generation R Study, a population-based prospective cohort study

Research output: Contribution to journalArticleAcademicpeer-review

52 Downloads (Pure)

Abstract

Objective: The primary objective of this study is to establish maternal reference values of anti‐Müllerian hormone (AMH) in a fertile multi-ethnic urban pregnant population and to evaluate the effect of gestational age. The secondary objective of this study is to explore the association between AMH and placental biomarkers. Design: This study was embedded in the Generation R Study, an ongoing population-based prospective cohort study from early pregnancy onwards. Setting: City of Rotterdam, the Netherlands, out of hospital setting. Patients: In 5806 women, serum AMH levels were determined in early pregnancy (median 13.5 weeks; 95% range 10.5–17.2). Intervention(s): None. Main outcome measures: Maternal AMH levels in early pregnancy and its association with placental biomarkers, including human chorionic gonadotrophin (hCG), soluble fms-like tyrosine kinase-1 (sFLT), and placental growth factor (PLGF). Results: A nomogram of AMH in early pregnancy was developed. Serum AMH levels showed a decline with advancing gestational age. Higher AMH levels were associated with a higher level of the placental biomarkers hCG and sFLT in early pregnancy. This last association was predominantly mediated by hCG. AMH levels were negatively associated with PLGF levels. Conclusion: In this large study, we show that AMH levels in early pregnancy decrease with advancing gestational age. The association between AMH and the placental biomarkers hCG, sFLT, and PLGF suggests a better placental development with lower vascular resistance in mothers with higher AMH levels. Hence, AMH might be useful in predicting adverse pregnancy outcomes due to impaired placental development.

Original languageEnglish
Article numbere220320
JournalEndocrine Connections
Volume12
Issue number3
Early online date1 Dec 2022
DOIs
Publication statusPublished - Mar 2023

Bibliographical note

Funding Information:
JSEL has received fees or grant support in the most recent 5-year period from the following organizations (in alphabetical order): Ansh Labs, Dutch Heart Foundation, Dutch Medical Research Counsel (ZonMW), Ferring, Roche Diagnostics and Titus Healthcare.

Funding Information:
The Generation R Study was funded through Erasmus Medical Center, Erasmus University Rotterdam, the Netherlands Organization for Health Research and Development, the Netherlands Organization for Scientific Research, the Ministry of Health, Welfare and Sport, and the Ministry of Youth and Families. The current study was made possible by an unrestricted research grant from Ansh Labs, Webster, TX, USA, for this particular project (JSEL).

Funding Information:
We gladly acknowledge the participation of all participants and the contribution of the general practitioners, hospitals, midwives and the pharmacies in Rotterdam and all those concerned in the Generation R Study. The Generation R Study was conducted by the Erasmus Medical Center, Rotterdam, the Netherlands, in close collaboration with: the school of Law and the Faculty of Social Sciences of the Erasmus University, Rotterdam, the Netherlands. Furthermore, we gratefully acknowledge Municipal Health Service, Rotterdam area; the Rotterdam homecare foundation; the Stichting Trombosedienst; and Artsenlaboratorium Rijnmond, Rotterdam.The Generation R Study was funded through Erasmus Medical Center, Erasmus University Rotterdam, the Netherlands Organization for Health Research and Development, the Netherlands Organization for Scientific Research, the Ministry of Health, Welfare and Sport, and the Ministry of Youth and Families. The current study was made possible by an unrestricted research grant from Ansh Labs, Webster, TX, USA, for this particular project (JSEL).

Publisher Copyright:
© 2023 The authors Published by Bioscientifica Ltd.

Fingerprint

Dive into the research topics of 'Reference ranges of anti‐Müllerian hormone and interaction with placental biomarkers in early pregnancy: the Generation R Study, a population-based prospective cohort study'. Together they form a unique fingerprint.

Cite this