Reference Values for Paravertebral Muscle Size and Myosteatosis in Chinese Adults, a Nationwide Multicenter Study

Wenkai Wu; Fangfang Duan; Kai Li; Wenshuang Zhang; Yi Yuan; Zetong Zang; Guihe Yang; Chuqi Li; Qian Zhao; Yan dong Liu; Ning Li; Kangkang Ma; Fengyun Zhou; Zitong Cheng; Jian Geng; Yuyu Liang; Renxian Wang; Xiaoguang Cheng; Ling Oei; Ling Wang; Yajun Liu

doi:10.1016/j.acra.2024.02.005

Reference Values for Paravertebral Muscle Size and Myosteatosis in Chinese Adults, a Nationwide Multicenter Study

Wenkai Wu, Fangfang Duan, Kai Li, Wenshuang Zhang, Yi Yuan, Zetong Zang, Guihe Yang, Chuqi Li, Qian Zhao, Yan dong Liu, Ning Li, Kangkang Ma, Fengyun Zhou, Zitong Cheng, Jian Geng, Yuyu Liang, Renxian Wang, Xiaoguang Cheng, Ling Oei, Ling WangYajun Liu^*

^*Corresponding author for this work

Internal Medicine

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

Abstract

Rationale and Objectives:

The paravertebral muscles, characterized by their susceptibility to severe size loss and fat infiltration in old age, lack established reference values for age-related variations in muscle parameters. This study aims to fill this gap by establishing reference values for paravertebral muscles in a Chinese adult population.

Materials and Methods:

This cross-sectional study utilized the baseline data from the prospective cohort China Action on Spine and Hip (CASH). A total of 4305 community-dwelling participants aged 21–80 years in China were recruited between 2013 and 2017. Pregnant women, individuals with metal implants, limited mobility or diseases/conditions (spinal tumor, infection, etc.) affecting lumbar vertebra were excluded from the study. Psoas and paraspinal muscles were measured in quantitative computed tomography (QCT) images at the L3 and L5 levels using Osirix software. Age-related reference values for muscle area, density, and fat fraction were constructed as percentile charts using the lambda-mu-sigma (LMS) method.

Results:

The paravertebral muscles exhibited an age-related decline in muscle area and density, coupled with an increase in muscle fat fraction. Between the ages of 25 and 75, the reductions in psoas and paraspinal muscle cross-sectional area at the L3 level were − 0.47%/yr and − 0.53%/yr in men, and − 0.19%/yr and − 0.23%/yr in women, respectively. Notably, accelerated muscle loss was observed during menopause and postmenopause in women (45–75 years) and intermittently during middle and old age in men (35–55 and 60–75 years). Besides, the age-related decreases in PSMA, PMA, and PSMD and the increases in PSMFF were more pronounced in L5 than in L3

Conclusion:

This study shows distinct patterns of accelerated muscle loss were identified in menopausal and postmenopausal women and in middle-aged and old men. The findings contribute valuable information for future investigations on paravertebral muscle loss and myosteatosis.

Original language	English
Pages (from-to)	2887-2896
Number of pages	10
Journal	Academic Radiology
Volume	31
Issue number	7
DOIs	https://doi.org/10.1016/j.acra.2024.02.005
Publication status	Published - Jul 2024

Bibliographical note

Publisher Copyright:
© 2024 The Association of University Radiologists

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10.1016/j.acra.2024.02.005

Cite this

Wu, W., Duan, F., Li, K., Zhang, W., Yuan, Y., Zang, Z., Yang, G., Li, C., Zhao, Q., Liu, Y. D., Li, N., Ma, K., Zhou, F., Cheng, Z., Geng, J., Liang, Y., Wang, R., Cheng, X., Oei, L., ... Liu, Y. (2024). Reference Values for Paravertebral Muscle Size and Myosteatosis in Chinese Adults, a Nationwide Multicenter Study. Academic Radiology, 31(7), 2887-2896. https://doi.org/10.1016/j.acra.2024.02.005

@article{69a39345561543f2b3b5b4be983ef6d3,

title = "Reference Values for Paravertebral Muscle Size and Myosteatosis in Chinese Adults, a Nationwide Multicenter Study",

abstract = "Rationale and Objectives: The paravertebral muscles, characterized by their susceptibility to severe size loss and fat infiltration in old age, lack established reference values for age-related variations in muscle parameters. This study aims to fill this gap by establishing reference values for paravertebral muscles in a Chinese adult population. Materials and Methods: This cross-sectional study utilized the baseline data from the prospective cohort China Action on Spine and Hip (CASH). A total of 4305 community-dwelling participants aged 21–80 years in China were recruited between 2013 and 2017. Pregnant women, individuals with metal implants, limited mobility or diseases/conditions (spinal tumor, infection, etc.) affecting lumbar vertebra were excluded from the study. Psoas and paraspinal muscles were measured in quantitative computed tomography (QCT) images at the L3 and L5 levels using Osirix software. Age-related reference values for muscle area, density, and fat fraction were constructed as percentile charts using the lambda-mu-sigma (LMS) method. Results: The paravertebral muscles exhibited an age-related decline in muscle area and density, coupled with an increase in muscle fat fraction. Between the ages of 25 and 75, the reductions in psoas and paraspinal muscle cross-sectional area at the L3 level were − 0.47%/yr and − 0.53%/yr in men, and − 0.19%/yr and − 0.23%/yr in women, respectively. Notably, accelerated muscle loss was observed during menopause and postmenopause in women (45–75 years) and intermittently during middle and old age in men (35–55 and 60–75 years). Besides, the age-related decreases in PSMA, PMA, and PSMD and the increases in PSMFF were more pronounced in L5 than in L3 Conclusion: This study shows distinct patterns of accelerated muscle loss were identified in menopausal and postmenopausal women and in middle-aged and old men. The findings contribute valuable information for future investigations on paravertebral muscle loss and myosteatosis.",

author = "Wenkai Wu and Fangfang Duan and Kai Li and Wenshuang Zhang and Yi Yuan and Zetong Zang and Guihe Yang and Chuqi Li and Qian Zhao and Liu, {Yan dong} and Ning Li and Kangkang Ma and Fengyun Zhou and Zitong Cheng and Jian Geng and Yuyu Liang and Renxian Wang and Xiaoguang Cheng and Ling Oei and Ling Wang and Yajun Liu",

note = "Publisher Copyright: {\textcopyright} 2024 The Association of University Radiologists",

year = "2024",

month = jul,

doi = "10.1016/j.acra.2024.02.005",

language = "English",

volume = "31",

pages = "2887--2896",

journal = "Academic Radiology",

issn = "1076-6332",

publisher = "Elsevier Inc.",

number = "7",

}

Wu, W, Duan, F, Li, K, Zhang, W, Yuan, Y, Zang, Z, Yang, G, Li, C, Zhao, Q, Liu, YD, Li, N, Ma, K, Zhou, F, Cheng, Z, Geng, J, Liang, Y, Wang, R, Cheng, X, Oei, L, Wang, L & Liu, Y 2024, 'Reference Values for Paravertebral Muscle Size and Myosteatosis in Chinese Adults, a Nationwide Multicenter Study', Academic Radiology, vol. 31, no. 7, pp. 2887-2896. https://doi.org/10.1016/j.acra.2024.02.005

TY - JOUR

T1 - Reference Values for Paravertebral Muscle Size and Myosteatosis in Chinese Adults, a Nationwide Multicenter Study

AU - Wu, Wenkai

AU - Duan, Fangfang

AU - Li, Kai

AU - Zhang, Wenshuang

AU - Yuan, Yi

AU - Zang, Zetong

AU - Yang, Guihe

AU - Li, Chuqi

AU - Zhao, Qian

AU - Liu, Yan dong

AU - Li, Ning

AU - Ma, Kangkang

AU - Zhou, Fengyun

AU - Cheng, Zitong

AU - Geng, Jian

AU - Liang, Yuyu

AU - Wang, Renxian

AU - Cheng, Xiaoguang

AU - Oei, Ling

AU - Wang, Ling

AU - Liu, Yajun

PY - 2024/7

Y1 - 2024/7

N2 - Rationale and Objectives: The paravertebral muscles, characterized by their susceptibility to severe size loss and fat infiltration in old age, lack established reference values for age-related variations in muscle parameters. This study aims to fill this gap by establishing reference values for paravertebral muscles in a Chinese adult population. Materials and Methods: This cross-sectional study utilized the baseline data from the prospective cohort China Action on Spine and Hip (CASH). A total of 4305 community-dwelling participants aged 21–80 years in China were recruited between 2013 and 2017. Pregnant women, individuals with metal implants, limited mobility or diseases/conditions (spinal tumor, infection, etc.) affecting lumbar vertebra were excluded from the study. Psoas and paraspinal muscles were measured in quantitative computed tomography (QCT) images at the L3 and L5 levels using Osirix software. Age-related reference values for muscle area, density, and fat fraction were constructed as percentile charts using the lambda-mu-sigma (LMS) method. Results: The paravertebral muscles exhibited an age-related decline in muscle area and density, coupled with an increase in muscle fat fraction. Between the ages of 25 and 75, the reductions in psoas and paraspinal muscle cross-sectional area at the L3 level were − 0.47%/yr and − 0.53%/yr in men, and − 0.19%/yr and − 0.23%/yr in women, respectively. Notably, accelerated muscle loss was observed during menopause and postmenopause in women (45–75 years) and intermittently during middle and old age in men (35–55 and 60–75 years). Besides, the age-related decreases in PSMA, PMA, and PSMD and the increases in PSMFF were more pronounced in L5 than in L3 Conclusion: This study shows distinct patterns of accelerated muscle loss were identified in menopausal and postmenopausal women and in middle-aged and old men. The findings contribute valuable information for future investigations on paravertebral muscle loss and myosteatosis.

AB - Rationale and Objectives: The paravertebral muscles, characterized by their susceptibility to severe size loss and fat infiltration in old age, lack established reference values for age-related variations in muscle parameters. This study aims to fill this gap by establishing reference values for paravertebral muscles in a Chinese adult population. Materials and Methods: This cross-sectional study utilized the baseline data from the prospective cohort China Action on Spine and Hip (CASH). A total of 4305 community-dwelling participants aged 21–80 years in China were recruited between 2013 and 2017. Pregnant women, individuals with metal implants, limited mobility or diseases/conditions (spinal tumor, infection, etc.) affecting lumbar vertebra were excluded from the study. Psoas and paraspinal muscles were measured in quantitative computed tomography (QCT) images at the L3 and L5 levels using Osirix software. Age-related reference values for muscle area, density, and fat fraction were constructed as percentile charts using the lambda-mu-sigma (LMS) method. Results: The paravertebral muscles exhibited an age-related decline in muscle area and density, coupled with an increase in muscle fat fraction. Between the ages of 25 and 75, the reductions in psoas and paraspinal muscle cross-sectional area at the L3 level were − 0.47%/yr and − 0.53%/yr in men, and − 0.19%/yr and − 0.23%/yr in women, respectively. Notably, accelerated muscle loss was observed during menopause and postmenopause in women (45–75 years) and intermittently during middle and old age in men (35–55 and 60–75 years). Besides, the age-related decreases in PSMA, PMA, and PSMD and the increases in PSMFF were more pronounced in L5 than in L3 Conclusion: This study shows distinct patterns of accelerated muscle loss were identified in menopausal and postmenopausal women and in middle-aged and old men. The findings contribute valuable information for future investigations on paravertebral muscle loss and myosteatosis.

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U2 - 10.1016/j.acra.2024.02.005

DO - 10.1016/j.acra.2024.02.005

M3 - Article

C2 - 38494349

AN - SCOPUS:85188008219

SN - 1076-6332

VL - 31

SP - 2887

EP - 2896

JO - Academic Radiology

JF - Academic Radiology

IS - 7

ER -

Reference Values for Paravertebral Muscle Size and Myosteatosis in Chinese Adults, a Nationwide Multicenter Study

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