@inbook{4cc424e5e43c4e25b5cc95349ccfc590,
title = "Regional cardiac hemodynamics and oxygenation during isovolemic hemodilution in anesthetized pigs",
abstract = "Hemodilution causes a drop in hematocrit, thereby lowering the oxygen carrying capacity of blood, necessitating an increase in flow or an augmented oxygen extraction by the tissues to meet their oxygen demands. Under normal conditions the myocardial oxygen extraction is already high and the capacity to increase is limited. In the heart the decrease in arterial oxygen content during hemodilution therefore is mainly compensated by an increase in coronary flow. This increase in flow can be achieved by both reduction of the blood viscosity and coronary vasodilatation. The hemodynamic changes during hemodilution may increase myocardial oxygen consumption and, therefore, an even greater increase in coronary flow might be needed.",
author = "{van Woerkens}, {E C} and A Trouwborst and Duncker, {D J} and Verdouw, {P D}",
year = "1992",
doi = "10.1007/978-1-4615-3428-0_64",
language = "English",
isbn = "978-1-4613-6516-7",
volume = "317",
series = "Advances in experimental medicine and biology",
publisher = "Springer New York",
pages = "545--52",
editor = "Wilhelm Erdmann and Bruley, {Duane F.}",
booktitle = "Oxygen Transport to Tissue XIV",
edition = "1st",
}