Regulation of gonadotropin receptor gene expression

Axel P.N. Themmen; Robert Kraaij; J. Anton Grootegoed

doi:10.1016/0303-7207(94)90272-0

Regulation of gonadotropin receptor gene expression

Axel P.N. Themmen^*
, Robert Kraaij
, J. Anton Grootegoed

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

27 Citations (Scopus)

Abstract

The receptors for the gonadotropins differ from the other G protein-coupled receptors by having a large extracellular hormone-binding domain, encoded by nine or ten exons. Alternative splicing of the large pre-mRNA of approximately 100 kb can result in mRNA species that encode truncated receptor proteins. In this review we discuss the regulation of gonadotropin receptor mRNA expression and the possible roles of alternative splicing in gonadotropin receptor function.

Original language	English
Pages (from-to)	15-19
Number of pages	5
Journal	Molecular and Cellular Endocrinology
Volume	100
Issue number	1-2
DOIs	https://doi.org/10.1016/0303-7207(94)90272-0
Publication status	Published - Apr 1994

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10.1016/0303-7207(94)90272-0

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title = "Regulation of gonadotropin receptor gene expression",

abstract = "The receptors for the gonadotropins differ from the other G protein-coupled receptors by having a large extracellular hormone-binding domain, encoded by nine or ten exons. Alternative splicing of the large pre-mRNA of approximately 100 kb can result in mRNA species that encode truncated receptor proteins. In this review we discuss the regulation of gonadotropin receptor mRNA expression and the possible roles of alternative splicing in gonadotropin receptor function.",

author = "Themmen, \{Axel P.N.\} and Robert Kraaij and \{Anton Grootegoed\}, J.",

year = "1994",

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T1 - Regulation of gonadotropin receptor gene expression

AU - Themmen, Axel P.N.

AU - Kraaij, Robert

AU - Anton Grootegoed, J.

PY - 1994/4

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N2 - The receptors for the gonadotropins differ from the other G protein-coupled receptors by having a large extracellular hormone-binding domain, encoded by nine or ten exons. Alternative splicing of the large pre-mRNA of approximately 100 kb can result in mRNA species that encode truncated receptor proteins. In this review we discuss the regulation of gonadotropin receptor mRNA expression and the possible roles of alternative splicing in gonadotropin receptor function.

AB - The receptors for the gonadotropins differ from the other G protein-coupled receptors by having a large extracellular hormone-binding domain, encoded by nine or ten exons. Alternative splicing of the large pre-mRNA of approximately 100 kb can result in mRNA species that encode truncated receptor proteins. In this review we discuss the regulation of gonadotropin receptor mRNA expression and the possible roles of alternative splicing in gonadotropin receptor function.

UR - https://www.scopus.com/pages/publications/0028351869

U2 - 10.1016/0303-7207(94)90272-0

DO - 10.1016/0303-7207(94)90272-0

M3 - Article

C2 - 8056149

AN - SCOPUS:0028351869

SN - 0303-7207

VL - 100

SP - 15

EP - 19

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

IS - 1-2

ER -

Regulation of gonadotropin receptor gene expression

Abstract

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