Regulation of microtubule dynamic instability

Babet Vaart, Anna Akhmanova, A Straube

Research output: Contribution to journalArticleAcademicpeer-review

113 Citations (Scopus)

Abstract

Proper regulation of MT (microtubule) dynamics is essential for various vital processes, including the segregation of chromosomes, directional cell migration and differentiation. MT assembly and disassembly is modulated by a complex network of intracellular factors that co-operate or antagonize each other, are highly regulated in space and time and are thus attuned to the cell cycle and differentiation processes. While we only begin to appreciate how the concerted action of MT stabilizers and destabilizers shapes different MT patterns, a clear picture of how individual factors affect the MT structure is emerging. in this paper, we review the current knowledge about proteins that modulate MT dynamic instability.
Original languageUndefined/Unknown
Pages (from-to)1007-1013
Number of pages7
JournalBiochemical Society Transactions
Volume37
DOIs
Publication statusPublished - 2009

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