Relapse primary central nervous system lymphoma successfully consolidated with allogeneic stem cell transplantation with thiotepa/busulfan/fludarabine conditioning

DP Noij, M van den Bent, JK Doorduijn, N Wlazlo

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Abstract

Primary central nervous system lymphoma (PCNSL) is generally characterized by a poor prognosis and frequent relapsing disease. Consolidation therapy in the upfront setting usually consists of an autologous stem cell transplantation. We report the case of a 19-year-old Caucasian male who had previously undergone an allogeneic stem cell transplantation with complete engraftment for the treatment of juvenile myelomonocytic leukemia when he was 1 year old. He presented with two episodes of (donor-derived) PCNSL from allogeneic stem cells; however, after induction chemotherapy, he failed to harvest stem cells for the consolidation with autologous stem cell transplantation. He was consolidated successfully with a second allogeneic stem cell transplantation with another donor after conditioning with thiotepa, busulfan, and fludarabine.
Original languageEnglish
Pages (from-to)366-370
Number of pages5
JournalActa Haematologica
Volume147
Issue number3
Early online date3 Oct 2023
DOIs
Publication statusPublished - 3 Oct 2023

Bibliographical note

Publisher Copyright:
© 2023 The Author(s). Published by S. Karger AG, Basel.

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