Relation of genetic profile and novel circulating biomarkers with coronary plaque phenotype as determined by intravascular ultrasound: rationale and design of the ATHEROREMO-IVUS study

Sanneke Boer, Jin Ming Cheng, Hector Garcia Garcia, Rohit Oemrawsingh, Robert Jan van Geuns, Evelyn Regar, Felix Zijlstra, R Laaksonen, E Halperin, ME Kleber, W Koenig, Eric Boersma, PWJC (Patrick) Serruys

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Abstract

Aims: The European Collaborative Project on Inflammation and Vascular Wall Remodeling in Atherosclerosis Intravascular Ultrasound (ATHEROREMO-IVUS) study aims to investigate the relations of genetic profile and novel circulating biomarkers with coronary plaque phenotype and vulnerability as determined by intravascular ultrasound (IVUS). Methods and results: ATHEROREMO-IVUS is a prospective, observational cohort study of 846 patients with stable angina pectoris or acute coronary syndrome (ACS) who are referred for coronary angiography. Prior to the catheterisation procedure, blood samples are drawn for biomarker measurements and genetic analyses. During the catheterisation procedure, IVUS is performed in a non-culprit coronary artery. The primary endpoint is the presence of vulnerable plaque as determined by IVUS virtual histology. Secondary end-points include the incidence of major adverse cardiac events during long-term follow-up. Conclusions: Results from ATHEROREMO-IVUS are expected to improve our knowledge of the role of genetic profile and circulating biomarkers in relation to the development of atherosclerosis and vulnerable plaques. Assessment and early validation of the prognostic value of novel biomarkers and intracoronary imaging techniques will be performed. (ClinicalTrials.gov number: NCT01789411).
Original languageUndefined/Unknown
Pages (from-to)953-960
Number of pages8
JournalEuroIntervention
Volume10
Issue number8
Publication statusPublished - 2014

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