Relationship of human papillomavirus with seborrheic keratosis of the female genital tract-a case-series and literature review

Shatavisha Dasgupta*, Rachel van Eersel, Beth Morrel, Henk A.M. van den Munckhof, Vera A. de Geus, Nick M.A. van der Hoeven, Miekel M. van de Sandt, Marta Piso-Jozwiak, Wim G.V. Quint, Irene A.M. van der Avoort, Senada Koljenović, Patricia C. Ewing-Graham, Folkert J. van Kemenade

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

4 Citations (Scopus)
9 Downloads (Pure)


Seborrheic keratoses (SKs) are benign lesions of uncertain etiology, which can develop in both genital and extra-genital locations. For genital SKs there has been conjecture about the pathogenic role of human papillomavirus (HPV), in view of the frequent association of this virus with genital lesions. In light of the potential consequences on patient management, we investigated the relationship between HPV and SKs of the female genital tract (FGT). For this, we evaluated the current evidence on this relationship by performing an in-depth review of the literature. Furthermore, to add to the evidence on this association, we investigated the presence of HPV in a series of vulvar SKs (n=15), using a novel multimodal approach. This involved whole tissue section-polymerase chain reaction (WTS-PCR) using SPF10-DEIA-LiPA25 for HPV detection and genotyping. In addition, immunohistochemistry (IHC) was performed with cellular biomarkers p16 and MIB-1, and viral biomarker E4, to augment HPV-testing. Finally, laser-capture microdissection-PCR (LCM-PCR) was performed to locate HPV to specific lesional cells, and to rule out incidental detection of resident HPV with WTS-PCR. Our findings from the literature review as well as the case-series are presented.

Original languageEnglish
Pages (from-to)1209-1218
Number of pages10
JournalHistology and Histopathology
Issue number12
Publication statusPublished - Dec 2021

Bibliographical note

Publisher Copyright: © The Author(s) 2021.


Dive into the research topics of 'Relationship of human papillomavirus with seborrheic keratosis of the female genital tract-a case-series and literature review'. Together they form a unique fingerprint.

Cite this