Remifentanil during cardiac surgery is associated with chronic thoracic pain 1 yr after sternotomy

L van Gulik, Sabine Ahlers, EMW van de Garde, P Bruins, WJ van Boven, Dick Tibboel, EPA van Dongen, Catherijne Knibbe

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Chronic thoracic pain after cardiac surgery is a serious condition affecting many patients. The aim of this study was to identify predictors for chronic thoracic pain after sternotomy in cardiac surgery patients by analysing patient and perioperative characteristics. A follow-up study was performed in 120 patients who participated in a clinical trial on pain levels in the early postoperative period after cardiac surgery. The presence of chronic thoracic pain was evaluated by a questionnaire 1 yr after surgery. Patients with and without chronic thoracic pain were compared. Associations were studied using multivariable logistic regression analysis. Questionnaires of 90 patients were analysed. Chronic thoracic pain was reported by 18 patients (20). In the multivariable regression model, remifentanil during cardiac surgery, age below 69 yr, and a body mass index above 28 kg m(2) were independent predictors for chronic thoracic pain {odds ratios 8.9 [95 confidence interval (CI) 1.649.0], 7.0 (95 CI 1.631.7), 9.1 (95 CI 2.139.1), respectively}. No differences were observed in patient and perioperative characteristics between patients receiving In this follow-up study in cardiac surgery patients, intraoperative remifentanil was predictive for chronic thoracic pain in a dose-dependent manner. Randomized studies designed to evaluate the influence of intraoperative remifentanil on chronic thoracic pain are needed to confirm these results.
Original languageUndefined/Unknown
Pages (from-to)616-622
Number of pages7
JournalBritish Journal of Anaesthesia
Issue number4
Publication statusPublished - 2012

Research programs

  • EMC MGC-02-53-01-A

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