Renal Biology Driven Macro- And Microscale Design Strategies for Creating an Artificial Proximal Tubule Using Fiber-Based Technologies

Ijsbrand M. Vermue; Runa Begum; Miguel Castilho; Maarten B. Rookmaaker; Rosalinde Masereeuw; Carlijn V.C. Bouten; Marianne C. Verhaar; Caroline Cheng

doi:10.1021/acsbiomaterials.1c00408

Renal Biology Driven Macro- And Microscale Design Strategies for Creating an Artificial Proximal Tubule Using Fiber-Based Technologies

Ijsbrand M. Vermue, Runa Begum, Miguel Castilho, Maarten B. Rookmaaker, Rosalinde Masereeuw, Carlijn V.C. Bouten, Marianne C. Verhaar, Caroline Cheng^*

^*Corresponding author for this work

Cardiology

Research output: Contribution to journal › Review article › Academic › peer-review

2 Citations (Scopus)

13 Downloads (Pure)

Abstract

Chronic kidney disease affects one in six people worldwide. Due to the scarcity of donor kidneys and the complications associated with hemodialysis (HD), a cell-based bioartificial kidney (BAK) device is desired. One of the shortcomings of HD is the lack of active transport of solutes that would normally be performed by membrane transporters in kidney epithelial cells. Specifically, proximal tubule (PT) epithelial cells play a major role in the active transport of metabolic waste products. Therefore, a BAK containing an artificial PT to actively transport solutes between the blood and the filtrate could provide major therapeutic advances. Creating such an artificial PT requires a biocompatible tubular structure which supports the adhesion and function of PT-specific epithelial cells. Ideally, this scaffold should structurally replicate the natural PT basement membrane which consists mainly of collagen fibers. Fiber-based technologies such as electrospinning are therefore especially promising for PT scaffold manufacturing. This review discusses the use of electrospinning technologies to generate an artificial PT scaffold for ex vivo/in vivo cellularization. We offer a comparison of currently available electrospinning technologies and outline the desired scaffold properties required to serve as a PT scaffold. Discussed also are the potential technologies that may converge in the future, enabling the effective and biomimetic incorporation of synthetic PTs in to BAK devices and beyond.

Original language	English
Pages (from-to)	4679-4693
Number of pages	15
Journal	ACS Biomaterials Science and Engineering
Volume	7
Issue number	10
DOIs	https://doi.org/10.1021/acsbiomaterials.1c00408
Publication status	Published - 11 Oct 2021

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Funding Information:
This research was financially supported by the Gravitation Program “Materials Driven Regeneration”, funded by The Netherlands Organization for Scientific Research (024.003.013) and by the TKI-LSH funded project Biocompatible polymer scaffold design for the Renal reABsorption unit (BIORAB). Figures were created with BioRender.com .

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Vermue, I. M., Begum, R., Castilho, M., Rookmaaker, M. B., Masereeuw, R., Bouten, C. V. C., Verhaar, M. C., & Cheng, C. (2021). Renal Biology Driven Macro- And Microscale Design Strategies for Creating an Artificial Proximal Tubule Using Fiber-Based Technologies. ACS Biomaterials Science and Engineering, 7(10), 4679-4693. https://doi.org/10.1021/acsbiomaterials.1c00408

@article{c9e24678707c4a028ba3c9c7f3948f75,

title = "Renal Biology Driven Macro- And Microscale Design Strategies for Creating an Artificial Proximal Tubule Using Fiber-Based Technologies",

abstract = "Chronic kidney disease affects one in six people worldwide. Due to the scarcity of donor kidneys and the complications associated with hemodialysis (HD), a cell-based bioartificial kidney (BAK) device is desired. One of the shortcomings of HD is the lack of active transport of solutes that would normally be performed by membrane transporters in kidney epithelial cells. Specifically, proximal tubule (PT) epithelial cells play a major role in the active transport of metabolic waste products. Therefore, a BAK containing an artificial PT to actively transport solutes between the blood and the filtrate could provide major therapeutic advances. Creating such an artificial PT requires a biocompatible tubular structure which supports the adhesion and function of PT-specific epithelial cells. Ideally, this scaffold should structurally replicate the natural PT basement membrane which consists mainly of collagen fibers. Fiber-based technologies such as electrospinning are therefore especially promising for PT scaffold manufacturing. This review discusses the use of electrospinning technologies to generate an artificial PT scaffold for ex vivo/in vivo cellularization. We offer a comparison of currently available electrospinning technologies and outline the desired scaffold properties required to serve as a PT scaffold. Discussed also are the potential technologies that may converge in the future, enabling the effective and biomimetic incorporation of synthetic PTs in to BAK devices and beyond. ",

author = "Vermue, {Ijsbrand M.} and Runa Begum and Miguel Castilho and Rookmaaker, {Maarten B.} and Rosalinde Masereeuw and Bouten, {Carlijn V.C.} and Verhaar, {Marianne C.} and Caroline Cheng",

note = "Funding Information: This research was financially supported by the Gravitation Program “Materials Driven Regeneration”, funded by The Netherlands Organization for Scientific Research (024.003.013) and by the TKI-LSH funded project Biocompatible polymer scaffold design for the Renal reABsorption unit (BIORAB). Figures were created with BioRender.com . Publisher Copyright: {\textcopyright} ",

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doi = "10.1021/acsbiomaterials.1c00408",

language = "English",

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Renal Biology Driven Macro- And Microscale Design Strategies for Creating an Artificial Proximal Tubule Using Fiber-Based Technologies. / Vermue, Ijsbrand M.; Begum, Runa; Castilho, Miguel et al.
In: ACS Biomaterials Science and Engineering, Vol. 7, No. 10, 11.10.2021, p. 4679-4693.

Research output: Contribution to journal › Review article › Academic › peer-review

TY - JOUR

T1 - Renal Biology Driven Macro- And Microscale Design Strategies for Creating an Artificial Proximal Tubule Using Fiber-Based Technologies

AU - Vermue, Ijsbrand M.

AU - Begum, Runa

AU - Castilho, Miguel

AU - Rookmaaker, Maarten B.

AU - Masereeuw, Rosalinde

AU - Bouten, Carlijn V.C.

AU - Verhaar, Marianne C.

AU - Cheng, Caroline

N1 - Funding Information: This research was financially supported by the Gravitation Program “Materials Driven Regeneration”, funded by The Netherlands Organization for Scientific Research (024.003.013) and by the TKI-LSH funded project Biocompatible polymer scaffold design for the Renal reABsorption unit (BIORAB). Figures were created with BioRender.com . Publisher Copyright: ©

PY - 2021/10/11

Y1 - 2021/10/11

N2 - Chronic kidney disease affects one in six people worldwide. Due to the scarcity of donor kidneys and the complications associated with hemodialysis (HD), a cell-based bioartificial kidney (BAK) device is desired. One of the shortcomings of HD is the lack of active transport of solutes that would normally be performed by membrane transporters in kidney epithelial cells. Specifically, proximal tubule (PT) epithelial cells play a major role in the active transport of metabolic waste products. Therefore, a BAK containing an artificial PT to actively transport solutes between the blood and the filtrate could provide major therapeutic advances. Creating such an artificial PT requires a biocompatible tubular structure which supports the adhesion and function of PT-specific epithelial cells. Ideally, this scaffold should structurally replicate the natural PT basement membrane which consists mainly of collagen fibers. Fiber-based technologies such as electrospinning are therefore especially promising for PT scaffold manufacturing. This review discusses the use of electrospinning technologies to generate an artificial PT scaffold for ex vivo/in vivo cellularization. We offer a comparison of currently available electrospinning technologies and outline the desired scaffold properties required to serve as a PT scaffold. Discussed also are the potential technologies that may converge in the future, enabling the effective and biomimetic incorporation of synthetic PTs in to BAK devices and beyond.

AB - Chronic kidney disease affects one in six people worldwide. Due to the scarcity of donor kidneys and the complications associated with hemodialysis (HD), a cell-based bioartificial kidney (BAK) device is desired. One of the shortcomings of HD is the lack of active transport of solutes that would normally be performed by membrane transporters in kidney epithelial cells. Specifically, proximal tubule (PT) epithelial cells play a major role in the active transport of metabolic waste products. Therefore, a BAK containing an artificial PT to actively transport solutes between the blood and the filtrate could provide major therapeutic advances. Creating such an artificial PT requires a biocompatible tubular structure which supports the adhesion and function of PT-specific epithelial cells. Ideally, this scaffold should structurally replicate the natural PT basement membrane which consists mainly of collagen fibers. Fiber-based technologies such as electrospinning are therefore especially promising for PT scaffold manufacturing. This review discusses the use of electrospinning technologies to generate an artificial PT scaffold for ex vivo/in vivo cellularization. We offer a comparison of currently available electrospinning technologies and outline the desired scaffold properties required to serve as a PT scaffold. Discussed also are the potential technologies that may converge in the future, enabling the effective and biomimetic incorporation of synthetic PTs in to BAK devices and beyond.

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U2 - 10.1021/acsbiomaterials.1c00408

DO - 10.1021/acsbiomaterials.1c00408

M3 - Review article

C2 - 34490771

AN - SCOPUS:85115620809

SN - 2373-9878

VL - 7

SP - 4679

EP - 4693

JO - ACS Biomaterials Science and Engineering

JF - ACS Biomaterials Science and Engineering

IS - 10

ER -

Renal Biology Driven Macro- And Microscale Design Strategies for Creating an Artificial Proximal Tubule Using Fiber-Based Technologies

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