Renal plasma flow: glomerular filtration rate relationships in man during direct renin inhibition with aliskiren

AE Splenser, NDL Fisher, Jan Danser, NK Hollenberg

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Abstract

We examined the relation between change in renal plasma flow (RPF) and change in glomerular filtration rate (GFR) in healthy humans on a low-salt diet during direct renin inhibition with aliskiren. We measured the renal hemodynamic response to acute dosing of 300 mg aliskiren by mouth to 19 healthy normotensive subjects (age, 33 3 years; baseline RPF, 575 23; GFR, 138 14 mL/min/1.73 m(2)) on a low-sodium diet (10 mmol/day). GFR and RPF were measured by the clearance of inulin and para-aminohippurate. There was a marked increase in average RPF (169124 mL/min/1.73 m(2)) and a small rise in average GFR (1.4 +/- 5 mL/min/1.73 m(2)) from baseline in response to aliskiren. There was a clear correlation between the change in RPF and the change in GFR between subjects (r = 0.65; P < .003). A Substantial increase in RPF was accompanied by a rise in GFR. Dependence of GFR on RPF was identified in healthy humans after RPF rose significantly with aliskiren. The responsible mechanism likely involves intravascular oncotic pressure along the glomerular capillary resulting in greater surface area available for filtration. J Am Soc Hypertens 2009;3(5):3 15-320. (C) 2009 American Society of Hypertension. All fights reserved.
Original languageUndefined/Unknown
Pages (from-to)315-320
Number of pages6
JournalJournal of the American Society of Hypertension
Volume3
Issue number5
DOIs
Publication statusPublished - 2009

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