Renin and prorenin as biomarkers in hypertension

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Abstract

Purpose of review This review examines the evidence that plasma renin and/or prorenin level may be used to guide therapy in hypertension and as an independent risk factor for future cardiovascular events. Recent findings A large number of retrospective analyses of patient populations in clinical trials, in whom 'baseline' renin measurements were available, supports that high renin, but not high prorenin levels, are indicative of future cardiovascular disease and death, particularly in patients with kidney dysfunction and/or hypertension. The relationship is not affected by the use of renin-angiotensin system (RAS) blockers. High renin levels also tend to support the use of RAS inhibitors as first-choice antihype Summary Measuring 'baseline' renin as a marker of future cardiovascular events or to determine the choice of drug is of limited value in an individual patient.
Original languageUndefined/Unknown
Pages (from-to)508-514
Number of pages7
JournalCurrent Opinion in Nephrology and Hypertension
Volume21
Issue number5
DOIs
Publication statusPublished - 2012

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