Reporting and Methods in Clinical Prediction Research: A Systematic Review

W (Walter) Bouwmeester, NPA Zuithoff, S Mallett, MI (Miriam) Geerlings, Yvonne Vergouwe, Ewout Steyerberg, DG Altman, KGM (Karel) Moons

Research output: Contribution to journalArticleAcademicpeer-review

405 Citations (Scopus)
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Background: We investigated the reporting and methods of prediction studies, focusing on aims, designs, participant selection, outcomes, predictors, statistical power, statistical methods, and predictive performance measures. Methods and Findings: We used a full hand search to identify all prediction studies published in 2008 in six high impact general medical journals. We developed a comprehensive item list to systematically score conduct and reporting of the studies, based on recent recommendations for prediction research. Two reviewers independently scored the studies. We retrieved 71 papers for full text review: 51 were predictor finding studies, 14 were prediction model development studies, three addressed an ex Conclusions: The majority of prediction studies in high impact journals do not follow current methodological recommendations, limiting their reliability and applicability.
Original languageUndefined/Unknown
JournalPLoS Medicine (print)
Issue number5
Publication statusPublished - 2012

Research programs

  • EMC NIHES-02-65-01

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